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变光斑尺寸对边缘照明 X 射线相衬成像中对比度通道的影响。

The effect of a variable focal spot size on the contrast channels retrieved in edge-illumination X-ray phase contrast imaging.

机构信息

Nikon X-Tek Systems Ltd, Tring, Herts, HP23 4JX, UK.

Department of Medical Physics and Biomedical Engineering, UCL, London, WC1E 6BT, UK.

出版信息

Sci Rep. 2022 Mar 1;12(1):3354. doi: 10.1038/s41598-022-07376-0.

DOI:10.1038/s41598-022-07376-0
PMID:35233022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8888612/
Abstract

Multi-modal X-ray imaging allows the extraction of phase and dark-field (or "Ultra-small Angle Scatter") images alongside conventional attenuation ones. Recently, scan-based systems using conventional sources that can simultaneously output the above three images on relatively large-size objects have been developed by various groups. One limitation is the need for some degree of spatial coherence, achieved either through the use of microfocal sources, or by placing an absorption grating in front of an extended source. Both these solutions limit the amount of flux available for imaging, with the latter also leading to a more complex setup with additional alignment requirements. Edge-illumination partly overcomes this as it was proven to work with focal spots of up to 100 micron. While high-flux, 100 micron focal spot sources do exist, their comparatively large footprint and high cost can be obstacles to widespread translation. A simple solution consists in placing a single slit in front of a large focal spot source. We used a tunable slit to study the system performance at various effective focal spot sizes, by extracting transmission, phase and dark-field images of the same specimens for a range of slit widths. We show that consistent, repeatable results are obtained for varying X-ray statistics and effective focal spot sizes. As the slit width is increased, the expected reduction in the raw differential phase peaks is observed, compensated for in the retrieval process by a broadened sensitivity function. This leads to the same values being correctly retrieved, but with a slightly larger error bar i.e. a reduction in phase sensitivity. Concurrently, a slight increase in the dark-field signal is also observed.

摘要

多模态 X 射线成像是指在提取相位和暗场(或“超小角散射”)图像的同时,还可以获取传统衰减图像。最近,各个研究小组开发出了基于扫描的系统,这些系统可以使用常规光源同时输出上述三种图像,且适用于较大尺寸的物体。但是,该系统有一个局限性,即需要一定程度的空间相干性,这可以通过使用微焦点源或者在扩展光源前放置吸收光栅来实现。这两种解决方案都限制了成像可用的通量,后者还会导致更复杂的设置,需要额外的对准要求。边缘照明在一定程度上克服了这个问题,因为它已被证明可以与直径高达 100 微米的焦点光斑配合使用。虽然存在高通量、100 微米焦点光斑源,但由于其较大的光斑尺寸和较高的成本,可能会阻碍其广泛应用。一个简单的解决方案是在大焦点光斑源前放置一个狭缝。我们使用可调狭缝来研究不同有效焦点光斑尺寸下的系统性能,通过对同一标本进行一系列狭缝宽度的透射、相位和暗场成像,来提取相同的图像。我们表明,对于不同的 X 射线统计数据和有效焦点光斑尺寸,可以获得一致、可重复的结果。随着狭缝宽度的增加,预期会观察到原始差分相位峰的降低,在检索过程中通过扩展灵敏度函数进行补偿。这会导致正确检索到相同的值,但误差幅度略大,即相位灵敏度降低。同时,还观察到暗场信号略有增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/450287bb87d4/41598_2022_7376_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/1a02928ced96/41598_2022_7376_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/90c68725d6a4/41598_2022_7376_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/c77a7b0a5ad0/41598_2022_7376_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/1d7b83d40a22/41598_2022_7376_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/b7213a61e0f3/41598_2022_7376_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/b2d6ac99dc7e/41598_2022_7376_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/288896ffe166/41598_2022_7376_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/2bbc8269acbc/41598_2022_7376_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/450287bb87d4/41598_2022_7376_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/1a02928ced96/41598_2022_7376_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/90c68725d6a4/41598_2022_7376_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/c77a7b0a5ad0/41598_2022_7376_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/1d7b83d40a22/41598_2022_7376_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/b7213a61e0f3/41598_2022_7376_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/b2d6ac99dc7e/41598_2022_7376_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/288896ffe166/41598_2022_7376_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/2bbc8269acbc/41598_2022_7376_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f47b/8888612/450287bb87d4/41598_2022_7376_Fig9_HTML.jpg

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