疟疾免疫力是否可能对 COVID-19 的严重症状和结局起到保护作用？
Is malaria immunity a possible protection against severe symptoms and outcomes of COVID-19?
机构信息
Department of Microbiology and Immunology, School of Medicine, University of Health and Allied Sciences, Ho, Volta Region, Ghana.
Centre for Malaria Research, Institute for Health Research, University of Health and Allied Sciences, Ho, Volta Region, Ghana.
出版信息
Ghana Med J. 2021 Jun;55(2 Suppl):56-63. doi: 10.4314/gmj.v55i2s.9.
UNLABELLED
Malaria-endemic areas of the world are noted for high morbidity and mortality from malaria. Also noted in these areas is the majority of persons in the population having acquired malaria immunity. Though this acquired malaria immunity does not prevent infection, it resists the multiplication of parasites, restricting disease to merely uncomplicated cases or asymptomatic infections. Does this acquired malaria immunity in endemic areas protect against other diseases, especially outbreak diseases like COVID-19? Does malaria activation of innate immunity resulting in trained or tolerance immunity contribute to protection against COVID-19? In an attempt to answer these questions, this review highlights the components of malaria and viral immunity and explores possible links with immunity against COVID-19. With malaria-endemic areas of the world having a fair share of cases of COVID-19, it is important to direct research in this area to evaluate and harness any benefits of acquired malaria immunity to help mitigate the effects of COVID-19 and any possible future outbreaks.
FUNDING
None declared.
无标签
世界上疟疾流行地区的特点是疟疾发病率和死亡率高。在这些地区，大多数人已经获得了疟疾免疫力。尽管这种获得性疟疾免疫力不能预防感染，但它可以阻止寄生虫的繁殖，将疾病限制在单纯的非复杂性病例或无症状感染。这种在流行地区获得的疟疾免疫力是否可以预防其他疾病，特别是像 COVID-19 这样的爆发性疾病？疟疾激活先天免疫导致训练或耐受免疫是否有助于预防 COVID-19？为了回答这些问题，本综述强调了疟疾和病毒免疫的组成部分，并探讨了与 COVID-19 免疫的可能联系。由于世界上疟疾流行地区有相当数量的 COVID-19 病例，因此重要的是在这一领域进行研究，以评估和利用获得性疟疾免疫力的任何益处，以帮助减轻 COVID-19 的影响和任何可能的未来爆发。
资助情况
无申报。
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