Choi Jong Hee, Lee Young Hyun, Kwon Tae Woo, Ko Seong-Gyu, Nah Seung-Yeol, Cho Ik-Hyun
Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
J Ginseng Res. 2022 May;46(3):337-347. doi: 10.1016/j.jgr.2022.02.006. Epub 2022 Feb 25.
Coronavirus disease 2019 (COVID-19) is currently a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 are directly associated with hyper-activation of innate immune response that excessively produce pro-inflammatory cytokines and induce cytokine storm, leading to multi-organ-failure and significant morbidity/mortality. Currently, several antiviral drugs such as Paxlovid (nirmatrelvir and ritonavir) and molnupiravir are authorized to treat mild to moderate COVID-19, however, there are still no drugs that can specifically fight against challenges of SARS-CoV-2 variants. a medicinal plant widely used for treating various conditions, might be appropriate for this need due to its anti-inflammatory/cytokine/viral activities, fewer side effects, and cost efficiency. To review and its pharmacologically active-ingredients as potential phytopharmaceuticals for treating cytokine storm of COVID-19, articles that reporting its positive effects on the cytokine production were searched from academic databases. Experimental/clinical evidences for the effectiveness of and its active-ingredients in preventing or mitigating cytokine storm, especially for the cascade of cytokine storm, suggest that they might be beneficial as an adjunct treatment for cytokine storm of COVID-19. This review may provide a new approach to discover specific medications using to control cytokine storm of COVID-19.
2019冠状病毒病（COVID-19）是目前由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的大流行病。COVID-19与先天免疫反应的过度激活直接相关，这种过度激活会过度产生促炎细胞因子并引发细胞因子风暴，导致多器官功能衰竭和显著的发病率/死亡率。目前，几种抗病毒药物，如帕罗韦德（奈玛特韦和利托那韦）和莫努匹拉韦被批准用于治疗轻至中度COVID-19，然而，仍然没有能够特异性对抗SARS-CoV-2变体挑战的药物。一种广泛用于治疗各种病症的药用植物，由于其抗炎/抗细胞因子/抗病毒活性、较少的副作用和成本效益，可能适合这一需求。为了综述[植物名称未给出]及其药理活性成分作为治疗COVID-19细胞因子风暴的潜在植物药，从学术数据库中搜索了报告其对细胞因子产生有积极影响的文章。[植物名称未给出]及其活性成分在预防或减轻细胞因子风暴，特别是细胞因子风暴级联反应方面的有效性的实验/临床证据表明，它们作为COVID-19细胞因子风暴的辅助治疗可能是有益的。本综述可能提供一种新的方法，利用[植物名称未给出]发现控制COVID-19细胞因子风暴的特定药物。
