Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), 110029 New Delhi, India.
Front Biosci (Landmark Ed). 2021 Apr 30;26(5):51-75. doi: 10.52586/4924.
In 2020, a novel strain of coronavirus (COVID-19) has led to a significant morbidity and mortality worldwide. As of the date of this writing, a total of 116 M cases has been diagnosed worldwide leading to 2.5 M deaths. The number of mortalities is directly correlated with the rise of innate immune cells (especially macrophages) in the lungs that secrete inflammatory cytokines (IL-1β and IL-6) leading to the development of "Cytokine Storm Syndrome" (CSS), multi-organ-failure and death. Given that currently the treatment of this condition is rare and release of effective vaccine might be months away, here, we review the plants and their pharmacologically active-compounds as potential phytopharmaceuticals for the virus induced inflammatory response. Experimental validation of the effectiveness of these natural compounds to prevent or reduce the cytokine storm might be beneficial as an adjunct treatment of SARS-CoV-2.
2020 年，一种新型冠状病毒（COVID-19）导致了全球范围内的高发病率和死亡率。截至本文撰写之日，全球共诊断出 11600 万例病例，导致 250 万人死亡。死亡率与肺部固有免疫细胞（尤其是巨噬细胞）的升高直接相关，这些细胞会分泌炎症细胞因子（IL-1β 和 IL-6），导致“细胞因子风暴综合征”（CSS）、多器官衰竭和死亡。鉴于目前这种疾病的治疗方法很少，而有效的疫苗可能需要数月时间才能研发出来，在这里，我们回顾了植物及其具有药理活性的化合物作为治疗病毒引起的炎症反应的潜在植物药。这些天然化合物在预防或减少细胞因子风暴方面的有效性的实验验证可能对 COVID-19 的治疗有辅助作用。
