Tao Ziwen, Li Yueyue, Cheng Baoquan, Zhou Tao, Gao Yanjing
Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
J Clin Transl Hepatol. 2022 Feb 28;10(1):164-173. doi: 10.14218/JCTH.2021.00171. Epub 2021 Sep 22.
Nonalcoholic fatty liver disease (NAFLD) is reported to affect 20-30% of adults and is accompanied by various metabolic comorbidities, where the economic and clinical burden of NAFLD is attributed to the progression of liver disease as well as the presence of extrahepatic diseases. Chronic kidney disease (CKD), which has a high incidence rate, high morbidity and mortality rates, and high medical costs, has been linked to NAFLD. CKD is associated with some metabolism-related risk factors that overlap with metabolic comorbidities of NAFLD. Therefore, to investigate the potential factors that influence CKD occurrence, the association between NAFLD and CKD should be clarified. Some studies have confirmed that NAFLD influences the occurrence and severity of CKD, whereas some studies have indicated that there is no correlation. In this review, the results of a few studies have been discussed, the potential risk factors for CKD in NAFLD are explored, and the respective biological mechanisms are elaborated to help clinicians identify CKD in patients much earlier than it is diagnosed now and thus help in reducing the incidence of liver and kidney transplants.
据报道，非酒精性脂肪性肝病（NAFLD）影响20%-30%的成年人，并伴有各种代谢合并症，其中NAFLD的经济和临床负担归因于肝脏疾病的进展以及肝外疾病的存在。慢性肾脏病（CKD）发病率高、患病率和死亡率高且医疗成本高，已与NAFLD相关联。CKD与一些与代谢相关的危险因素有关，这些因素与NAFLD的代谢合并症重叠。因此，为了研究影响CKD发生的潜在因素，应阐明NAFLD与CKD之间的关联。一些研究证实NAFLD会影响CKD的发生和严重程度，而一些研究表明两者之间没有相关性。在这篇综述中，讨论了一些研究的结果，探讨了NAFLD中CKD的潜在危险因素，并阐述了各自的生物学机制，以帮助临床医生比目前更早地识别患者的CKD，从而有助于降低肝肾移植的发生率。
