• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

烟酰胺甲基转移酶在人类癌症中的预后价值：来自一项荟萃分析和数据库验证的证据。

Prognostic value of nicotinamide -methyltransferase in human cancers: Evidence from a meta-analysis and database validation.

作者信息

Dang Ling, Wang Yingdong

机构信息

Department of Digestive Internal Medicine, People's Hospital of Tongchuan, Tongchuan, Shaanxi, 727000, China.

Department of Abdominal Oncology, Shaanxi Provincial Cancer Hospital, Xi'an, Shaanxi, 710061, China.

出版信息

Open Med (Wars). 2022 Feb 14;17(1):292-303. doi: 10.1515/med-2022-0413. eCollection 2022.

DOI:10.1515/med-2022-0413
PMID:35233465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8847710/
Abstract

BACKGROUND

Previous studies indicated that dysregulated expression of nicotinamide -methyltransferase (NNMT) contributed to the tumor progression and predicted poor prognosis in various cancers. However, there was no exact conclusion on account of the contradictory results across studies.

METHODS

The relevant studies up to December 7, 2020 were searched in PubMed, Web of Science, and Embase. The association between NNMT expression and prognostic outcomes was explored, including overall survival (OS), disease-free survival (DFS), and clinicopathological features. The bioinformatics database was used to validate the findings.

RESULTS

Thirteen retrospective studies containing 2,591 patients with cancers were included in this analysis. High NNMT expression was significantly associated with shorter OS (hazard ratio [HR] = 2.01, 95% confidence interval [CI] = 1.42-2.86, and < 0.01) and DFS (HR = 1.59, 95% CI = 1.23-2.05, and < 0.01) compared to low NNMT expression in cancers. Compared to patients with low NNMT expression, patients with high NNMT expression tended to have worse tumor differentiation ( = 0.03), earlier lymph node metastasis ( = 0.01), earlier distant metastasis ( = 0.02), and more advanced clinical stage ( < 0.01).

CONCLUSION

High NNMT expression is an unfavorable factor of various cancers. NNMT is a promising indicator to predict the prognosis of various cancers and can serve as a potential therapeutic target in various cancers.

摘要

背景

先前的研究表明，烟酰胺甲基转移酶（NNMT）表达失调促进肿瘤进展，并预示多种癌症预后不良。然而，由于各项研究结果相互矛盾，尚无确切结论。

方法

检索截至2020年12月7日的PubMed、Web of Science和Embase数据库中的相关研究。探讨NNMT表达与预后结果之间的关联，包括总生存期（OS）、无病生存期（DFS）及临床病理特征。利用生物信息学数据库验证研究结果。

结果

本分析纳入了13项回顾性研究，共2591例癌症患者。与癌症中低NNMT表达相比，高NNMT表达与较短的OS（风险比[HR]=2.01，95%置信区间[CI]=1.42 - 2.86，P<0.01）和DFS（HR = 1.59，95% CI = 1.23 - 2.05，P<0.01）显著相关。与低NNMT表达的患者相比，高NNMT表达的患者往往具有更差的肿瘤分化（P = 0.03）、更早的淋巴结转移（P = 0.01）、更早的远处转移（P = 0.02）以及更晚的临床分期（P<0.01）。

结论

高NNMT表达是多种癌症的不利因素。NNMT是预测多种癌症预后的有前景的指标，可作为多种癌症潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/0906dbb4228d/j_med-2022-0413-fig008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/c7806ab97b6a/j_med-2022-0413-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/ab283381723d/j_med-2022-0413-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/92842636d8b1/j_med-2022-0413-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/d7420f738a45/j_med-2022-0413-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/a4431df5bda0/j_med-2022-0413-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/c9b85406693a/j_med-2022-0413-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/1e177984a9d2/j_med-2022-0413-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/0906dbb4228d/j_med-2022-0413-fig008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/c7806ab97b6a/j_med-2022-0413-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/ab283381723d/j_med-2022-0413-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/92842636d8b1/j_med-2022-0413-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/d7420f738a45/j_med-2022-0413-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/a4431df5bda0/j_med-2022-0413-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/c9b85406693a/j_med-2022-0413-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/1e177984a9d2/j_med-2022-0413-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa3/8847710/0906dbb4228d/j_med-2022-0413-fig008.jpg

相似文献

1
Prognostic value of nicotinamide -methyltransferase in human cancers: Evidence from a meta-analysis and database validation.烟酰胺甲基转移酶在人类癌症中的预后价值：来自一项荟萃分析和数据库验证的证据。
Open Med (Wars). 2022 Feb 14;17(1):292-303. doi: 10.1515/med-2022-0413. eCollection 2022.
2
Overexpression of Nicotinamide N-methyltransferase mainly covers stroma of colorectal cancer and correlates with unfavorable survival by its product 1-MNA.烟酰胺N-甲基转移酶的过表达主要覆盖结直肠癌的基质，并通过其产物1-甲基烟酰胺与不良生存相关。
J Cancer. 2021 Aug 26;12(20):6170-6181. doi: 10.7150/jca.56419. eCollection 2021.
3
Prognostic Value of Nicotinamide N-Methyltransferase Expression in Patients With Solid Tumors: A Systematic Review and Meta-Analysis.烟酰胺N-甲基转移酶表达在实体瘤患者中的预后价值：一项系统评价和Meta分析
Front Physiol. 2018 Oct 8;9:1407. doi: 10.3389/fphys.2018.01407. eCollection 2018.
4
Patients with low nicotinamide N-methyltransferase expression benefit significantly from bevacizumab treatment in ovarian cancer.低烟酰胺 N-甲基转移酶表达的卵巢癌患者从贝伐珠单抗治疗中显著获益。
BMC Cancer. 2021 Jan 14;21(1):67. doi: 10.1186/s12885-021-07785-w.
5
Nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma.烟酰胺N-甲基转移酶过表达与Akt磷酸化相关，并提示鼻咽癌患者预后较差。
Tumour Biol. 2013 Dec;34(6):3923-31. doi: 10.1007/s13277-013-0980-z. Epub 2013 Jul 11.
6
Expression profile and prognostic value of NNMT in patients with pancreatic cancer.烟酰胺 N-甲基转移酶（NNMT）在胰腺癌患者中的表达谱及预后价值
Oncotarget. 2016 Apr 12;7(15):19975-81. doi: 10.18632/oncotarget.7891.
7
Overexpression of lncRNA SNGH3 Predicts Unfavorable Prognosis and Clinical Outcomes in Human Cancers: Evidence from a Meta-Analysis.长链非编码 RNA SNGH3 的过表达预测人类癌症的不良预后和临床结局：来自荟萃分析的证据。
Biomed Res Int. 2020 Jun 25;2020:7974034. doi: 10.1155/2020/7974034. eCollection 2020.
8
Correlation of NNMT and DKK1 Protein Expression With Clinicopathological Characteristics and Prognosis of Breast Cancer.NNMT和DKK1蛋白表达与乳腺癌临床病理特征及预后的相关性
Clin Med Insights Oncol. 2023 Apr 20;17:11795549231168073. doi: 10.1177/11795549231168073. eCollection 2023.
9
High stromal nicotinamide N-methyltransferase (NNMT) indicates poor prognosis in colorectal cancer.高基质烟酰胺 N-甲基转移酶（NNMT）预示结直肠癌预后不良。
Cancer Med. 2020 Mar;9(6):2030-2038. doi: 10.1002/cam4.2890. Epub 2020 Jan 27.
10
Accumulation of Nicotinamide N-Methyltransferase (NNMT) in Cancer-associated Fibroblasts: A Potential Prognostic and Predictive Biomarker for Gastric Carcinoma.烟酰胺 N-甲基转移酶（NNMT）在癌相关成纤维细胞中的积累：胃癌的一个潜在预后和预测生物标志物。
J Histochem Cytochem. 2021 Mar;69(3):165-176. doi: 10.1369/0022155420976590. Epub 2020 Dec 7.

引用本文的文献

1
Nicotinamide N-Methyltransferase (NNMT) and Liver Cancer: From Metabolic Networks to Therapeutic Targets.烟酰胺N-甲基转移酶（NNMT）与肝癌：从代谢网络到治疗靶点
Biomolecules. 2025 May 14;15(5):719. doi: 10.3390/biom15050719.
2
NNMT overexpression is an adverse prognostic factor in uterine leiomyosarcoma.NNMT 过表达是子宫平滑肌肉瘤的不良预后因素。
Turk J Med Sci. 2024 Apr 16;54(4):804-810. doi: 10.55730/1300-0144.5852. eCollection 2024.
3
Metabolic Signaling in Cancer Metastasis.癌症转移中的代谢信号。

本文引用的文献

1
Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells.烟酰胺N-甲基转移酶通过抑制乳腺癌细胞中的AMPK途径来抑制氧化应激诱导的自噬。
Cancer Cell Int. 2020 May 24;20:191. doi: 10.1186/s12935-020-01279-8. eCollection 2020.
2
High stromal nicotinamide N-methyltransferase (NNMT) indicates poor prognosis in colorectal cancer.高基质烟酰胺 N-甲基转移酶（NNMT）预示结直肠癌预后不良。
Cancer Med. 2020 Mar;9(6):2030-2038. doi: 10.1002/cam4.2890. Epub 2020 Jan 27.
3
Nicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial cancer.
Cancer Discov. 2024 Jun 3;14(6):934-952. doi: 10.1158/2159-8290.CD-24-0174.
4
Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer.综合生物信息学分析表明，整合素α3是胰腺癌的一种预后生物标志物。
Open Med (Wars). 2022 Dec 9;17(1):1935-1943. doi: 10.1515/med-2022-0606. eCollection 2022.
5
Systematic pan-cancer analysis of the nicotinamide n-methyltransferase in human cancer.人类癌症中烟酰胺N-甲基转移酶的系统性泛癌分析。
Front Genet. 2022 Oct 26;13:1000515. doi: 10.3389/fgene.2022.1000515. eCollection 2022.
烟酰胺 N-甲基转移酶表达及其与磷酸化 Akt、p53 表达和高级别子宫内膜癌生存的关系。
Turk J Med Sci. 2019 Oct 24;49(5):1547-1554. doi: 10.3906/sag-1907-166.
4
Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway.下调烟酰胺 N-甲基转移酶通过 Wnt/β-连环蛋白通路抑制食管鳞癌细胞的迁移和上皮-间充质转化。
Mol Cell Biochem. 2019 Oct;460(1-2):93-103. doi: 10.1007/s11010-019-03573-0. Epub 2019 Jul 5.
5
Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization.烟酰胺 N-甲基转移酶通过 SIRT1 蛋白稳定增强乳腺癌的化疗耐药性。
Breast Cancer Res. 2019 May 17;21(1):64. doi: 10.1186/s13058-019-1150-z.
6
Prognostic Value of Nicotinamide N-Methyltransferase Expression in Patients With Solid Tumors: A Systematic Review and Meta-Analysis.烟酰胺N-甲基转移酶表达在实体瘤患者中的预后价值：一项系统评价和Meta分析
Front Physiol. 2018 Oct 8;9:1407. doi: 10.3389/fphys.2018.01407. eCollection 2018.
7
Nicotinamide N-methyltransferase as a potential marker for cancer.烟酰胺 N-甲基转移酶作为癌症的潜在标志物。
Neoplasma. 2018 Sep 19;65(5):656-663. doi: 10.4149/neo_2018_171024N680. Epub 2018 Jun 18.
8
Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1.烟酰胺N-甲基转移酶通过稳定沉默调节蛋白1促进前列腺癌进展。
Oncol Lett. 2018 Jun;15(6):9195-9201. doi: 10.3892/ol.2018.8474. Epub 2018 Apr 12.
9
Prognostic and clinicopathological value of SIRT3 expression in various cancers: a systematic review and meta-analysis.SIRT3表达在各类癌症中的预后及临床病理价值：一项系统综述与荟萃分析
Onco Targets Ther. 2018 Apr 13;11:2157-2167. doi: 10.2147/OTT.S157836. eCollection 2018.
10
Nicotinamide N-methyltransferase promotes epithelial-mesenchymal transition in gastric cancer cells by activating transforming growth factor-β1 expression.烟酰胺N-甲基转移酶通过激活转化生长因子-β1的表达促进胃癌细胞的上皮-间质转化。
Oncol Lett. 2018 Apr;15(4):4592-4598. doi: 10.3892/ol.2018.7885. Epub 2018 Jan 26.