Hunan University of Medicine, Huaihua, China.
First People's Hospital of Huaihua City, Huaihua, China.
Neoplasma. 2018 Sep 19;65(5):656-663. doi: 10.4149/neo_2018_171024N680. Epub 2018 Jun 18.
Cancer is the main leading cause of death in the world, although it has been made noteworthy advances in cancer research in the past decades. Early detection of cancer is extremely important in improving the chances of successful therapy. Thus, it is urgently needed to make further efforts to explore novel tumor markers for treatment. Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme which catalyzes the N-methylation of nicotinamide to form 1-methylnicotinamide (1-MNA), and plays an important role in controlling the intracellular concentration of nicotinamide. Nicotinamide, the precursor to NAD+, is an important cofactor that associates cellular redox states with energy metabolism. Growing evidence shows that NNMT protein levels are elevated in a variety of human cancers, and increased NNMT expression has been linked to tumor aggressiveness. This paper presents a review for the role of NNMT expressed in a series of human cancers and the regulating mechanism involved, and offers its potential value of NNMT in cancer detection and treatment.
癌症是世界上主要的死亡原因，尽管在过去几十年中，癌症研究已经取得了显著的进展。癌症的早期检测对于提高成功治疗的机会极为重要。因此，迫切需要进一步努力探索新的肿瘤标志物用于治疗。烟酰胺 N-甲基转移酶（NNMT）是一种胞质酶，可催化烟酰胺的 N-甲基化形成 1-甲基烟酰胺（1-MNA），并在控制烟酰胺的细胞内浓度方面发挥重要作用。烟酰胺是 NAD+的前体，是将细胞氧化还原状态与能量代谢联系起来的重要辅因子。越来越多的证据表明，NNMT 蛋白水平在多种人类癌症中升高，并且增加的 NNMT 表达与肿瘤侵袭性相关。本文综述了 NNMT 在一系列人类癌症中的表达作用及其涉及的调节机制，并提供了 NNMT 在癌症检测和治疗中的潜在价值。
