Bende M, Laurin L
ORL J Otorhinolaryngol Relat Spec. 1986;48(4):238-42. doi: 10.1159/000275875.
The effect of a topically administered alpha-adrenoceptor agonist (phenylpropanolamine) after allergen challenge was evaluated in a placebo-controlled double-blind crossover study in 10 subjects with allergic rhinitis in an asymptomatic period. The nasal airway resistance was objectively measured by anterior rhinomanometry after nasal allergen challenge. The degree of nasal blockage, secretion and the number of sneezes were registered in a score. Nasal airway resistance and the degree of blockage were found to be significantly reduced. Thus, alpha-adrenoceptor agonists might be used topically for symptomatic treatment of allergic rhinitis comprising mucosal congestion.
在一项安慰剂对照的双盲交叉研究中，对10名处于无症状期的变应性鼻炎患者局部应用α-肾上腺素能受体激动剂（苯丙醇胺），评估其在变应原激发后的效果。在鼻内变应原激发后，通过前鼻测压法客观测量鼻气道阻力。以评分形式记录鼻阻塞、分泌物及喷嚏次数。发现鼻气道阻力和阻塞程度显著降低。因此，α-肾上腺素能受体激动剂可局部用于治疗包括黏膜充血在内的变应性鼻炎的症状。
