Empey D W, Frosolono M F, Hughes D T, Perkins J G
Br J Clin Pharmacol. 1984 Jul;18(1):86-9. doi: 10.1111/j.1365-2125.1984.tb05026.x.
The abilities of triprolidine 2.5 mg and pseudoephedrine 60 mg, alone and in combination, to protect against an increase in nasal airway resistance (NAR) after histamine challenge were determined in eighteen individuals with grass pollen allergy. The study was conducted outside the pollen season using a double-blind, placebo controlled crossover design. The prior administration of pseudoephedrine 60 mg and triprolidine 2.5 mg alone or in combination was superior to placebo in reducing the increase in NAR after challenge with 1.0% histamine. However, such NAR measurements did not differentiate between pseudoephedrine 60 mg and triprolidine 2.5 mg administered alone or in combination. Challenge with 0.1% histamine failed to discriminate between any of the test medications.
在18名对草花粉过敏的个体中，测定了2.5毫克曲普利啶和60毫克伪麻黄碱单独及联合使用时，预防组胺激发后鼻气道阻力（NAR）增加的能力。该研究在花粉季节之外进行，采用双盲、安慰剂对照的交叉设计。单独或联合预先给予60毫克伪麻黄碱和2.5毫克曲普利啶，在减轻1.0%组胺激发后NAR的增加方面优于安慰剂。然而，这种NAR测量无法区分单独或联合使用的60毫克伪麻黄碱和2.5毫克曲普利啶。用0.1%组胺激发未能区分任何一种受试药物。
