Zhejiang Cancer Institute (Experimental Research Center), Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, PR China.
The Second Clinical Medical College of Zhejiang Chinese Medicine University, Hangzhou, PR China.
Histol Histopathol. 2022 Apr;37(4):323-334. doi: 10.14670/HH-18-447. Epub 2022 Mar 2.
Histone methylation plays a crucial role in the regulation of gene transcriptional expression, and aberration of methylation-modifying enzyme genes can lead to a variety of genetic diseases, including human cancers. The histone modified protein KMT2 (lysin methyltransferase) family are involved in cell proliferation, growth, development and differentiation through regulating gene expression, and are closely related with many blood cancers and solid tumors. In recent years, several studies have shown that mutations in the KMT2 gene occur frequently in a variety of human cancers and the mutation status of the KMT2 gene may be correlated with the occurrence, development and prognosis of some tumors. Research uncovering the clinical characteristics and molecular mechanisms of KMT2 mutation in human tumors will be helpful for early diagnosis and prognosis of tumors as well as drug development for targeted therapies.
组蛋白甲基化在基因转录表达的调控中起着至关重要的作用，甲基化修饰酶基因的异常会导致多种遗传疾病，包括人类癌症。组蛋白修饰蛋白 KMT2（赖氨酸甲基转移酶）家族通过调节基因表达参与细胞增殖、生长、发育和分化，与许多血液癌症和实体瘤密切相关。近年来，多项研究表明，KMT2 基因突变在多种人类癌症中频繁发生，KMT2 基因突变状态可能与某些肿瘤的发生、发展和预后相关。研究揭示 KMT2 基因突变在人类肿瘤中的临床特征和分子机制，有助于肿瘤的早期诊断和预后以及靶向治疗药物的开发。
