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平行股的 d(CGA)双链是一种具有两种构象上明显不同链的高度可预测的结构基序。

The parallel-stranded d(CGA) duplex is a highly predictable structural motif with two conformationally distinct strands.

机构信息

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.

出版信息

Acta Crystallogr D Struct Biol. 2022 Mar 1;78(Pt 3):299-309. doi: 10.1107/S2059798322000304. Epub 2022 Feb 18.

DOI:10.1107/S2059798322000304
PMID:35234144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8900823/
Abstract

DNA can adopt noncanonical structures that have important biological functions while also providing structural diversity for applications in nanotechnology. Here, the crystal structures of two oligonucleotides composed of d(CGA) triplet repeats in the parallel-stranded duplex form are described. The structure determination of four unique d(CGA)-based parallel-stranded duplexes across two crystal structures has allowed the structural parameters of d(CGA) triplets in the parallel-stranded duplex form to be characterized and established. These results show that d(CGA) units are highly uniform, but that each strand in the duplex is structurally unique and has a distinct role in accommodating structural asymmetries induced by the C-CH base pair.

摘要

DNA 可以采用具有重要生物学功能的非规范结构，同时为纳米技术应用提供结构多样性。在这里，描述了两种由平行双链体中 d(CGA)三重复组成的寡核苷酸的晶体结构。通过两个晶体结构中四个独特的基于 d(CGA)的平行双链体的结构测定，已经能够对平行双链体形式中的 d(CGA)三重复的结构参数进行表征和建立。这些结果表明，d(CGA)单元非常均匀，但是双链体中的每条链在结构上都是独特的，并且在适应由 C-CH 碱基对引起的结构不对称性方面具有独特的作用。

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3
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4
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The Structure and Function of DNA G-Quadruplexes.
Trends Chem. 2020 Feb;2(2):123-136. doi: 10.1016/j.trechm.2019.07.002.
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Epigenetics Chromatin. 2020 Mar 5;13(1):12. doi: 10.1186/s13072-020-00334-y.
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