College of Pharmaceutical Science & Collaborative Innovation Centre of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 112024, China.
Org Biomol Chem. 2022 Mar 23;20(12):2370-2386. doi: 10.1039/d1ob02426d.
Pyrazolones and pyrazoles, featuring nitrogen-nitrogen bonds, are two of the most important classes of heterocycles, owing to their widespread occurrence in medicinal chemistry and functional materials. The last decade has witnessed a rapid increase in the construction of chiral pyrazolone and pyrazole derivatives, with the application of pyrazolone derivatives as powerful synthons. Since our last review in 2018, a large number of new achievements has emerged in this area, requiring a timely update. Thus, this review summarizes these elegant achievements based on the multiple reactive sites of different pyrazolone synthons. In addition, important mechanisms and interesting biological investigations relating to the corresponding products are also discussed.
吡唑酮和吡唑类化合物，具有氮-氮键，是最重要的杂环化合物之一，因为它们广泛存在于药物化学和功能材料中。在过去的十年中，由于吡唑酮衍生物作为强大的合成子的应用，手性吡唑酮和吡唑衍生物的构建迅速增加。自我们在 2018 年的上一次综述以来，这一领域出现了大量新的成果，需要及时更新。因此，本综述根据不同吡唑酮合成子的多个反应位点，总结了这些优雅的成就。此外，还讨论了与相应产物相关的重要机制和有趣的生物学研究。
