Department of Gynecology, Renmin Hospital, Hubei University of Medicine, Maojian District, No. 39, Chaoyang Zhong Road, Shiyan City, 442000, Hubei Province, China.
Ann Biomed Eng. 2022 May;50(5):485-498. doi: 10.1007/s10439-022-02909-0. Epub 2022 Mar 2.
Limited cell division and lack of endogenous repair mechanisms in the central nervous system, hampers tissue repair following neurodegenerative diseases or tissue injuries. Unlike central nervous system; peripheral nervous system has some capacity to repair after injury, but in case of critical sized defects the use of supporting cells in the neural guidance channels seems inevitable to obtain a satisfactory functional recovery. Stem cell therapies have provided new frontiers in the repair of nervous system largely through paracrine secretion mechanisms. The therapeutic potential of stem cells differs according to their tissue of origin, mode of isolation, administration route, and passage number. During the past decades, studies have been focused on stem cells harvested from disposable tissues such as menstrual blood or biopsies from endometrium. These cells are characterized by their high differentiation and proliferation potential, ease of harvest, and lack of ethical concerns. In the current review, we will discuss the prospects and challenges of endometrial stem cells' application in nervous system repair.
中枢神经系统的细胞分裂有限且缺乏内源性修复机制，这阻碍了神经退行性疾病或组织损伤后的组织修复。与中枢神经系统不同；外周神经系统在受伤后具有一定的修复能力，但在临界尺寸缺陷的情况下，使用神经引导通道中的支持细胞似乎是获得满意功能恢复的必然选择。干细胞疗法通过旁分泌分泌机制为神经系统的修复提供了新的前沿。干细胞的治疗潜力因组织来源、分离方式、给药途径和传代数的不同而不同。在过去的几十年中，研究集中在从可重复使用的组织中提取的干细胞上，如月经血或子宫内膜活检。这些细胞的特点是分化和增殖潜力高、易于采集且不存在伦理问题。在本综述中，我们将讨论子宫内膜干细胞在神经系统修复中的应用的前景和挑战。
