Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Department of Radiology, The First People's Hospital of Kashgar, Kashgar, China.
Muscle Nerve. 2020 Jun;61(6):815-825. doi: 10.1002/mus.26862. Epub 2020 Apr 6.
The immuno-microenvironment of injured nerves adversely affects mesenchymal stem cell (MSC) therapy for neurotmesis. Magnetic resonance imaging (MRI) can be used noninvasively to monitor nerve degeneration and regeneration. The aim of this study was to investigate nerve repair after MSC transplantation combined with microenvironment immunomodulation in neurotmesis by using multiparametric MRI.
Rats with sciatic nerve transection and surgical coaptation were treated with MSCs combined with immunomodulation or MSCs alone. Serial multiparametric MRI examinations were performed over an 8-week period after surgery.
Nerves treated with MSCs combined with immunomodulation showed better functional recovery, rapid recovery of nerve T2, fractional anisotropy and radial diffusivity values, and more rapid restoration of the fiber tracks than nerves treated with MSCs alone.
Transplantation of MSCs in combination with immunomodulation can exert a synergistic repair effect on neurotmesis, which can be monitored by multiparametric MRI.
受损神经的免疫微环境会对骨髓间充质干细胞（MSC）治疗神经断裂产生不利影响。磁共振成像（MRI）可用于非侵入性地监测神经变性和再生。本研究旨在通过多参数 MRI 研究 MSC 移植联合微环境免疫调节对神经断裂的神经修复作用。
对坐骨神经横断并手术吻合的大鼠进行 MSC 联合免疫调节或 MSC 单独治疗。术后 8 周内进行系列多参数 MRI 检查。
与单独使用 MSC 治疗的神经相比，联合使用 MSC 联合免疫调节治疗的神经表现出更好的功能恢复、更快的神经 T2、各向异性分数和径向弥散度值恢复以及更快的纤维束恢复。
MSC 联合免疫调节移植对神经断裂具有协同修复作用，可通过多参数 MRI 进行监测。
