Cardiac Arrhythmia Service, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Cardiac Electrophysiology, Mount Sinai School of Medicine, New York, NY, USA.
Curr Cardiol Rep. 2022 Feb;24(2):103-108. doi: 10.1007/s11886-021-01630-z. Epub 2022 Mar 2.
Current ablation approach for arrhythmias relies upon the use of radiofrequency (RF) and cryoablation catheters. Although there have been significant advances both in catheter design and in energy delivery approaches, limitations such as suboptimal efficacy and safety remain. Pulsed field ablation (PFA) has emerged as a novel approach to ablation that is distinct from RF and cryoablation by virtue of selective ablation of myocardial tissue. Preclinical and clinical reports have demonstrated lesion durability with an excellent safety profile. These findings need to be confirmed in prospective randomized trials that are currently ongoing. In this review, we describe efficacy and safety outcomes from both pre-clinical and clinical studies that have been performed so far and briefly discuss ongoing clinical trials and future investigations.
Data from pre-clinical and clinical research have shown PFA as a promising tool for ablation of cardiac arrhythmias. In addition to safety regarding mitigating the risk to surrounding structures such as the phrenic nerve, esophagus, PFA also offers an effective method for ablation. In this review, we summarize the currently published pre-clinical and clinical data evaluating the safety and efficacy of PFA for cardiac arrhythmias.
目前心律失常的消融方法依赖于射频（RF）和冷冻消融导管。尽管在导管设计和能量传递方法方面都取得了重大进展，但仍存在疗效和安全性不理想等局限性。脉冲场消融（PFA）作为一种新颖的消融方法，通过选择性消融心肌组织，与 RF 和冷冻消融有明显区别。临床前和临床报告显示，该方法具有持久的疗效和出色的安全性。这些发现需要在目前正在进行的前瞻性随机试验中得到证实。在这篇综述中，我们描述了迄今为止进行的临床前和临床研究的疗效和安全性结果，并简要讨论了正在进行的临床试验和未来的研究。
临床前和临床研究数据表明 PFA 是一种有前途的心律失常消融工具。除了能降低膈神经、食管等周围结构损伤的风险外，PFA 还提供了一种有效的消融方法。在这篇综述中，我们总结了目前发表的评估 PFA 治疗心律失常的安全性和有效性的临床前和临床数据。
