Department of Medicine, Cardiology Division, University of Virginia Health System: UVA Health, Charlottesville, VA, USA.
Curr Cardiol Rep. 2022 Jul;24(7):793-799. doi: 10.1007/s11886-022-01697-2. Epub 2022 May 24.
With catheter ablation of atrial fibrillation becoming increasingly common, the field of electrophysiology is searching for tools to improve procedural efficacy and safety. This review focuses on a novel ablation tool, pulsed field ablation, which promises to push the needle forward. Pulsed field ablation uses high-frequency electrical pulses to ablate cardiac tissue.
A number of pre-clinical and clinical studies have shown pulsed field ablation offers an efficient means of ablating cardiac tissue with minimal risk of collateral injury. Pulsed field ablation provides a non-thermal means of cardiac tissue ablation with minimal risk of injury to adjacent structures. Future studies will define the optimal current delivery, number of lesions needed to achieve the desired tissue effect, and how best to integrate pulsed field ablation catheters into 3-dimensional mapping systems.
随着房颤导管消融技术的日益普及，电生理领域正在寻找能够提高手术疗效和安全性的工具。本综述重点介绍了一种新的消融工具——脉冲电场消融，它有望推动该领域的发展。脉冲电场消融利用高频电脉冲来消融心肌组织。
多项临床前和临床研究表明，脉冲电场消融提供了一种有效消融心肌组织的方法，同时最大限度地降低了旁线损伤的风险。脉冲电场消融采用非热手段消融心肌组织，对邻近结构的损伤风险最小。未来的研究将确定最佳的电流传递方式、实现预期组织效果所需的消融灶数量，以及如何将脉冲电场消融导管最佳地整合到 3 维标测系统中。
