同型半胱氨酸过氧化物介导的对动脉前列环素合成的影响。

Peroxide mediated effects of homocysteine on arterial prostacyclin synthesis.

作者信息

Panganamala R V, Karpen C W, Merola A J

出版信息

Prostaglandins Leukot Med. 1986 Jun;22(3):349-56. doi: 10.1016/0262-1746(86)90145-9.

Abstract

The effects of homocysteine on the synthesis of arterial prostacyclin (PGI2) were investigated. Homocysteine at 10 mM and 1 mM concentration inhibited PGI2 synthesis from both exogenous and endogenous arachidonic acid. While concentrations of 100 microM and 1 microM stimulated PGI2 synthesis. Similar inhibitory effects of H2O2 on PGI2 synthesis were observed. High concentrations (100 microM and 500 microM) of H2O2 inhibited PGI2 production while low concentrations (1 microM) of H2O2 stimulated it. Catalase overcame the inhibitory effect of H2O2 (100 microM). Homocysteine induced O2 uptake and catalase inhibited the O2 uptake by homocysteine. Thus the inhibitory and stimulatory effect of homocysteine may be dependent on the oxidation of homocysteine and subsequent H2O2 generation.

摘要

研究了同型半胱氨酸对动脉前列环素（PGI2）合成的影响。10 mM和1 mM浓度的同型半胱氨酸抑制外源性和内源性花生四烯酸合成PGI2。而100 microM和1 microM的浓度则刺激PGI2合成。观察到过氧化氢（H2O2）对PGI2合成有类似的抑制作用。高浓度（100 microM和500 microM）的H2O2抑制PGI2生成，而低浓度（1 microM）的H2O2则刺激其生成。过氧化氢酶克服了H2O2（100 microM）的抑制作用。同型半胱氨酸诱导氧气摄取，而过氧化氢酶抑制同型半胱氨酸的氧气摄取。因此，同型半胱氨酸的抑制和刺激作用可能取决于同型半胱氨酸的氧化及随后过氧化氢的生成。