Maltby Vicki E, Lea Rodney A, Reeves Penny, Saugbjerg Bente, Lechner-Scott Jeannette
School of Medicine and Public Health, University of Newcastle, Callaghan, NSW 2308, Australia; Department of Neurology, John Hunter Hospital, New Lambton Heights, NSW 2310, Australia; Hunter Medical Research Institute, New Lambton, NSW, Australia.
School of Medicine and Public Health, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, New Lambton, NSW, Australia; Centre for Genomics and Personalised Health, School of Biomedical Science, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
Mult Scler Relat Disord. 2022 Apr;60:103707. doi: 10.1016/j.msard.2022.103707. Epub 2022 Feb 22.
Cognitive impairment is a common symptom of multiple sclerosis (MS). The effect of cognitive impairment in people with MS on employment, quality of life and mental health is known, however, few studies have investigated if cognitive deficits contribute to the economic burden of MS.
To investigate if cognitive impairment correlates with the economic burden of MS.
The client service receipt inventory was used to determine cost to the healthcare system, participant out of pocket cost, community cost and total societal cost. Quality of life was evaluated using the EuroQoL. Participants cognitive performance was assessed with the Audio Recorded Cognitive Screen and the symbol digit modalities test. Spearman's rank correlation coefficient (r) was used to gauge the strength of the correlation between domain scores and cost metrics.
Memory, speed of writing and the symbol digit modalities test were all negatively correlated with all aspects of cost of care (r = 0.24-0.59, P < 0.5). This was found to be independent of other factors, such as EDSS or mental health indices.
Cognitive deficits are independently correlated with the economic burden of MS and should be monitored as part of routine care.
认知障碍是多发性硬化症（MS）的常见症状。MS患者认知障碍对就业、生活质量和心理健康的影响已为人所知，然而，很少有研究调查认知缺陷是否会加重MS的经济负担。
调查认知障碍是否与MS的经济负担相关。
使用客户服务收据清单来确定医疗系统成本、参与者自付费用、社区成本和社会总成本。使用欧洲生活质量量表评估生活质量。参与者的认知表现通过录音认知筛查和符号数字模态测试进行评估。采用Spearman等级相关系数（r）来衡量领域得分与成本指标之间的相关强度。
记忆力、书写速度和符号数字模态测试均与护理成本的各个方面呈负相关（r = 0.24 - 0.59，P < 0.5）。发现这与其他因素无关，如扩展残疾状态量表（EDSS）或心理健康指数。
认知缺陷与MS的经济负担独立相关，应作为常规护理的一部分进行监测。
