Chen Mimi, Wang Jie, Zhou Shanlei, Zhang Cun, Deng Datong, Liu Fujun, Luo Wei, Zhu Jiajia, Yu Yongqiang
Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Front Hum Neurosci. 2022 Feb 14;16:773309. doi: 10.3389/fnhum.2022.773309. eCollection 2022.
: It has been reported that type 2 diabetes (T2DM) is associated with olfactory identification (OI) impairments and cognitive decline. However, the relationship between OI impairments and cognitive decline is largely unknown in T2DM patients. : Sixty-eight T2DM patients and 68 healthy controls underwent 3D-T1 MRI scans, olfactory and cognitive assessments. The cortical thickness of olfaction-related brain regions, olfactory and cognitive scores were compared between groups. Correlation analyses were carried out among cognition, olfaction, and cortical thickness of olfaction-related brain regions. : First, the cognitive and olfactory test scores of T2DM patients were lower than healthy subjects. Second, higher olfactory scores were associated with increased cortical thickness in the left parahippocampal gyrus and bilateral insula in T2DM. Third, higher olfactory scores were associated with higher cognitive performance in T2DM. Fourth, some cognitive performances were related to cortical thickness in the left parahippocampal gyrus and left insula in T2DM. : These findings indicated that olfactory dysfunction may be useful for future applications that attempt to predict cognitive decline or develop tailored therapies in T2DM patients.
据报道，2型糖尿病（T2DM）与嗅觉识别（OI）障碍及认知衰退有关。然而，在T2DM患者中，OI障碍与认知衰退之间的关系很大程度上尚不清楚。68名T2DM患者和68名健康对照者接受了三维T1磁共振成像扫描、嗅觉和认知评估。比较了两组之间嗅觉相关脑区的皮质厚度、嗅觉和认知得分。对认知、嗅觉以及嗅觉相关脑区的皮质厚度进行了相关性分析。首先，T2DM患者的认知和嗅觉测试得分低于健康受试者。其次，在T2DM患者中，较高的嗅觉得分与左侧海马旁回和双侧脑岛的皮质厚度增加有关。第三，在T2DM患者中，较高的嗅觉得分与较高的认知表现有关。第四，在T2DM患者中，一些认知表现与左侧海马旁回和左侧脑岛的皮质厚度有关。这些发现表明，嗅觉功能障碍可能有助于未来预测T2DM患者认知衰退或制定个性化治疗方案的应用。
