Zeng Weiqi, Fan Wenliang, Kong Xiangchuang, Liu Xiaoming, Liu Ling, Cao Ziqin, Zhang Xiaoqian, Yang Xiaoman, Cheng Chi, Wu Yi, Xu Yu, Cao Xuebing, Xu Yan
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Aging Neurosci. 2022 Feb 14;14:783634. doi: 10.3389/fnagi.2022.783634. eCollection 2022.
The aim of our study was to investigate differences in whole brain connectivity at different levels between drug-naïve individuals with early Parkinson's disease (PD) and healthy controls (HCs). Resting-state functional magnetic resonance imaging data were collected from 47 patients with early-stage, drug-naïve PD and 50 HCs. Functional brain connectivity was analyzed at the integrity, network, and edge levels; UPDRS-III, MMSE, MOCA, HAMA, and HAMD scores, reflecting the symptoms of PD, were collected for further regression analysis. Compared with age-matched HCs, reduced functional connectivity were mainly observed in the visual (VSN), somatomotor (SMN), limbic (LBN), and deep gray matter networks (DGN) at integrity level [ < 0.05, false discovery rate (FDR) corrected]. Intra-network analysis indicated decreased functional connectivity in DGN, SMN, LBN, and ventral attention networks (VAN). Inter-network analysis indicated reduced functional connectivity in nine pairs of resting-state networks. At the edge level, the LBN was the center of abnormal functional connectivity ( < 0.05, FDR corrected). MOCA score was associated with the intra-network functional connectivity strength (FC) of the DGN, and inter-network FC of the DGN-VAN. HAMA and HAMD scores were associated with the FC of the SMN and DGN, and either the LBN or VAN, respectively. We demonstrated variations in whole brain connections of drug-naïve patients with early PD. Major changes involved the SMN, DGN, LBN, and VSN, which may be relevant to symptoms of early PD. Additionally, our results support PD as a disconnection syndrome.
我们研究的目的是调查早期帕金森病（PD）未用药个体与健康对照（HCs）在不同水平上全脑连接性的差异。收集了47例早期、未用药的PD患者和50例HCs的静息态功能磁共振成像数据。在完整性、网络和边缘水平分析了脑功能连接性；收集了反映PD症状的统一帕金森病评定量表第三部分（UPDRS-III）、简易精神状态检查表（MMSE）、蒙特利尔认知评估量表（MOCA）、汉密尔顿焦虑量表（HAMA）和汉密尔顿抑郁量表（HAMD）评分，用于进一步的回归分析。与年龄匹配的HCs相比，在完整性水平上，主要在视觉（VSN）、躯体运动（SMN）、边缘（LBN）和深部灰质网络（DGN）中观察到功能连接性降低[<0.05，错误发现率（FDR）校正]。网络内分析表明，DGN、SMN、LBN和腹侧注意网络（VAN）中的功能连接性降低。网络间分析表明，九对静息态网络之间的功能连接性降低。在边缘水平，LBN是异常功能连接的中心（<0.05，FDR校正）。MOCA评分与DGN的网络内功能连接强度（FC）以及DGN-VAN的网络间FC相关。HAMA和HAMD评分分别与SMN和DGN的FC以及LBN或VAN的FC相关。我们证明了早期PD未用药患者全脑连接性的变化。主要变化涉及SMN、DGN、LBN和VSN，这可能与早期PD的症状有关。此外，我们的结果支持将PD视为一种连接障碍综合征。
