Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangdong Province, Guangzhou, 510080, China.
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China.
Neurol Sci. 2024 Jan;45(1):155-169. doi: 10.1007/s10072-023-07005-2. Epub 2023 Aug 14.
Our study aimed to explore the functional connectivity alterations between cortical nodes of resting-state networks in Parkinson's disease (PD) patients with wearing-off (WO) at different levels.
Resting-state functional magnetic resonance imaging was performed on 36 PD patients without wearing-off (PD-nWO), 30 PD patients with wearing-off (PD-WO), and 35 healthy controls (HCs) to extract functional networks. Integrity, network, and edge levels were calculated for comparison between groups. UPDRS-III, MMSE, MOCA, HAMA, and HAMD scores were collected for further regression analysis.
We observed significantly reduced connectivity strength in the dorsal attention network and limbic network in the PD-WO group compared with the HC group. The PD-WO group showed a decreased degree of functional connectivity at 12 nodes, including the bilateral orbital part of the superior frontal gyrus, right olfactory cortex, left medial orbital part of the superior frontal gyrus, bilateral gyrus rectus, right parahippocampal gyrus, right thalamus, left Heschl's gyrus, right superior temporal gyrus part of the temporal pole, left middle temporal gyrus part of the temporal pole, and right inferior temporal gyrus. Furthermore, the PD-WO group showed a significantly lower degree of functional connectivity in the left orbital part of the superior frontal gyrus and right gyrus rectus than the PD-nWO group. Internetwork analysis indicated reduced functional connectivity in five pairs of resting-state networks.
Our results demonstrated altered intra- and internetwork connections in PD patients with WO. These findings will facilitate a better understanding of the distinction between the network changes in PD pathophysiology.
本研究旨在探讨处于不同严重程度“开-关”期的帕金森病（PD）患者静息态网络皮质节点间功能连接的改变。
对 36 例无“开-关”期的 PD 患者（PD-nWO）、30 例有“开-关”期的 PD 患者（PD-WO）和 35 例健康对照者（HCs）进行静息态功能磁共振成像，提取功能网络。在组间比较中计算了完整性、网络和边缘水平。收集 UPDRS-III、MMSE、MOCA、HAMA 和 HAMD 评分进行进一步的回归分析。
与 HC 组相比，PD-WO 组的背侧注意网络和边缘网络的连接强度显著降低。PD-WO 组有 12 个节点的功能连接程度降低，包括双侧额上回眶部、右侧嗅皮质、左侧额上回眶部内侧、双侧直回、右侧海马旁回、右侧丘脑、左侧海氏回、右侧颞极额上回部分、左侧颞极额上回部分、右侧颞下回。此外，与 PD-nWO 组相比，PD-WO 组的左侧额上回眶部和右侧直回的功能连接程度显著降低。网络间分析表明，五个静息态网络对的功能连接降低。
我们的结果表明，WO 期 PD 患者存在内、网络间连接改变。这些发现将有助于更好地理解 PD 病理生理学中网络变化的区别。
