The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California San Diego, La Jolla, CA, United States.
Division of Medical Genetics, Department of Medicine, Bioinformatics and System Biology Program, University of California San Diego, La Jolla, CA, United States.
Front Immunol. 2022 Feb 14;13:823157. doi: 10.3389/fimmu.2022.823157. eCollection 2022.
The tumor-immune interface has surged to primary relevance in an effort to understand the hurdles facing immune surveillance and cancer immunotherapy. Reports over the past decades have indicated a role for the unfolded protein response (UPR) in modulating not only tumor cell fitness and drug resistance, but also local immunity, with emphasis on the phenotype and altered function of immune cells such as myeloid cells and T cells. Emerging evidence also suggests that aneuploidy correlates with local immune dysregulation. Recently, we reported that the UPR serves as a link between aneuploidy and immune cell dysregulation in a cell nonautonomous way. These new findings add considerable complexity to the organization of the tumor microenvironment (TME) and the origin of its altered function. In this review, we summarize these data and also discuss the role of aneuploidy as a negative regulator of local immunity.
肿瘤免疫界面在努力理解免疫监视和癌症免疫治疗所面临的障碍方面已经成为主要关注点。过去几十年来的报告表明，未折叠蛋白反应 (UPR) 在调节肿瘤细胞适应性和耐药性方面发挥作用，同时也调节局部免疫，重点是免疫细胞（如髓样细胞和 T 细胞）的表型和功能改变。新出现的证据还表明，非整倍体与局部免疫失调相关。最近，我们报道 UPR 以非自主的方式充当非整倍体与免疫细胞失调之间的联系。这些新发现为肿瘤微环境 (TME) 的组织和其功能改变的起源增加了相当大的复杂性。在这篇综述中，我们总结了这些数据，并讨论了非整倍体作为局部免疫负调节剂的作用。
