State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention (China CDC), Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China.
Front Immunol. 2022 Feb 14;13:824178. doi: 10.3389/fimmu.2022.824178. eCollection 2022.
The prevalence of CRF07_BC is 39.7% and has become the most infectious HIV strain in China. To study the transmission and diffusion trajectory of CRF07_BC in China and to prevent further expansion of its transmission. A total of 16,635 sequences of the CRF07_BC gene were collected from 1997-2020. We characterized the gene subtypes according to a phylogenetic tree analysis. A 0.50% molecular network was constructed to analyze the transmission relationship among different provinces for CRF07_BC and its two epidemic clusters. Spatial and temporal propagation characteristics were analyzed according to phylogeographic analysis. Finally, we evaluated the differences in transmission of CRF07_BC-O, and CRF07_BC-N. Our dataset included 8,816 sequences of CRF07_BC-N and 7,819 sequences of CRF07_BC-O. There were 7,132 CRF07_BC sequences in the molecular network, and the rate of clustered was 42.9%. Compared to CRF07_BC-O, CRF07_BC-N showed significantly (<0.001) higher transmission-specific rates. CRF07_BC originated among injecting drug users (IDUs), and spread to men who have sex with men (MSMs) and heterosexual individuals (HETs), while MSMs also transmitted directly to HETs. CRF07_BC-O and CRF07_BC-N were prevalent in Xinjiang and Sichuan, respectively, before spreading interprovincially. In modern China, CRF07_BC-N occurs in five of the major economic zones. The CRF07_BC strain, which has contributed to the highest number of HIV infections in China, is divided into two epidemic clusters. Compared with CRF07_BC-O, risk of transmission is much greater in CRF07_BC-N, which is predominantly prevalent in economically developed provinces, and both MSMs and IDUs have transmitted this epidemic cluster to HETs. High-resolution, large-scale monitoring is a useful tool in assessing the trend and spread of the HIV epidemic. The rapidly developing economy of China requires an equally rapid response to the prevention and control of infectious diseases.
中国流行的 CRF07_BC 占比为 39.7%，已成为中国最具传染性的 HIV 毒株。为研究 CRF07_BC 在我国的传播和扩散轨迹，防止其进一步传播。本研究共收集了 1997 年至 2020 年期间的 16635 份 CRF07_BC 基因序列。根据系统发育树分析对基因亚型进行了特征描述。构建了一个 0.50%的分子网络，分析了 CRF07_BC 及其两个流行簇在不同省份之间的传播关系。根据地理谱系分析，分析了时空传播特征。最后，评估了 CRF07_BC-O 和 CRF07_BC-N 的传播差异。我们的数据集中包含 8816 份 CRF07_BC-N 序列和 7819 份 CRF07_BC-O 序列。分子网络中有 7132 个 CRF07_BC 序列，聚类率为 42.9%。与 CRF07_BC-O 相比，CRF07_BC-N 的传播特定率显著更高(<0.001)。CRF07_BC 起源于静脉吸毒者 (IDUs)，并传播给男男性行为者 (MSM) 和异性恋者 (HET)，而 MSM 也直接将其传播给 HET。CRF07_BC-O 和 CRF07_BC-N 分别在新疆和四川流行，然后再在省内传播。在中国现代，CRF07_BC-N 出现在五个主要经济区。在中国导致 HIV 感染人数最多的 CRF07_BC 菌株分为两个流行簇。与 CRF07_BC-O 相比，CRF07_BC-N 的传播风险要大得多，主要在经济发达省份流行，MSM 和 IDU 均将该流行簇传播给 HET。高分辨率、大规模监测是评估 HIV 流行趋势和传播的有用工具。中国快速发展的经济需要对传染病的预防和控制做出同样迅速的反应。
