中国河北两例新型 HIV 第二重组形式的全长基因组分析。
Near-full-length genome analysis of two novel HIV second recombinant forms in Hebei, China.
机构信息
School of Public Health, Department of Public Health Laboratory Medicine, North China University of Science and Technology, No. 21 Bohai Road, Caofeidian District, 063210, Tangshan, Hebei, China.
Hebei Key Laboratory of Immune Mechanism of Major Infectious Diseases and New Technology of Diagnosis and Treatment, The Fifth Hospital of Shijiazhuang, Shijiazhuang, China.
出版信息
Arch Virol. 2024 Mar 18;169(4):76. doi: 10.1007/s00705-024-06007-5.
The number of individuals infected with HIV-1 among men who have sex with men (MSM) has risen rapidly in recent years in China, and the subtypes CRF01_AE, CRF07_BC, and B, as well as many novel unique recombinant forms (URFs) are prevalent among them. Co-circulation of strains among MSM populations allows the generation of circulating recombinant forms (CRFs) and URFs. In this study, we identified two new URFs from two HIV-1-positive subjects who were infected through homosexual contact in Hebei, China. Analysis of near-full-length genome sequences, using phylogenetic and recombination analysis showed that the two URFs originated from CRF01_AE, CRF07_BC, and B, and CRF01_AE segments in the backbone of the URFs were derived from cluster 4 of CRF01_AE. The CRF07_BC segments of two URFs were clustered with 07BC_N in a phylogenetic tree. The identification of novel URFs with complex genomic structures shows that it is necessary to strengthen surveillance of HIV-1 variants in MSM populations in this region.
近年来，中国男男性行为人群（MSM）中感染 HIV-1 的人数迅速增加，其中流行的亚型包括 CRF01_AE、CRF07_BC 和 B，以及许多新型独特重组形式（URF）。MSM 人群中菌株的共同循环允许产生循环重组形式（CRFs）和 URF。在这项研究中，我们从在中国河北通过同性恋接触感染的两名 HIV-1 阳性受试者中鉴定出两种新的 URF。对近乎全长基因组序列的分析，使用系统发育和重组分析表明，这两种 URF 起源于 CRF01_AE、CRF07_BC 和 B，URF 骨架中的 CRF01_AE 片段来自 CRF01_AE 簇 4。两个 URF 的 CRF07_BC 片段在系统发育树中与 07BC_N 聚类。新型具有复杂基因组结构的 URF 的鉴定表明，有必要加强对该地区 MSM 人群中 HIV-1 变异体的监测。
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