清热除痹汤治疗膝关节骨性关节炎的临床疗效分析及其对患者运动功能的影响。
Analysis of Clinical Efficacy of Clearing Heat and Dispelling Paralysis Soup in the Treatment of Osteoarthritis of the Knee Joint and Its Effect on Patients' Motor Function.
机构信息
The First Affiliated Hospital, Department of Rheumatology and Immunology, Hengyang Medical College, University of South China, Hengyang Hunan 421001, China.
出版信息
Comput Math Methods Med. 2022 Feb 21;2022:5104121. doi: 10.1155/2022/5104121. eCollection 2022.
OBJECTIVE
To investigate the effects of clearing heat and dispelling paralysis soup for osteoarthritis of the knee joint on the motor function of the knee joint and the level of inflammation of the organism in patients.
METHODS
One hundred and sixteen patients with knee osteoarthritis admitted from January 2020 to May 2021 were selected and randomly divided into 2 groups, 58 cases in the control group were treated with loxoprofen sodium dispersible tablets, and 58 cases in the experimental group were treated with Qinghe dispel paralysis soup on the basis of the control group and the patients' balance ability analysis, gait parameter change analysis, VAS, JOA, AIMS2-SF scale assessment, and serum index. The treatment effects of the two treatment regimens were analyzed by testing.
RESULTS
The anterior-posterior axis, left-right axis, A2-A6, A4-A8, and circumferential axis of the experimental group were lower than those of the control group after treatment ( < 0.05); the step length of the experimental group was higher than that of the control group after treatment ( < 0.05), and there were no significant differences in step speed, double-support phase, and step width ( > 0.05), but both groups improved significantly compared with those before treatment ( < 0.05); the VAS score of the experimental group was lower than that of the control group after treatment. The VAS scores of the experimental group were lower than those of the control group, and the scores of JOA and AIMS2-SF were higher than those of the control group ( < 0.05); the levels of TIMP-1 in the experimental group were higher than those in the control group, and the levels of TNF-, TLR4, MMP-3, and IL-1 were lower than those in the control group after treatment ( < 0.05); there was no significant difference in the incidence of adverse reactions between the two groups during treatment ( > 0.05), and the efficiency of the experimental group was higher than that of the control group ( < 0.05).
CONCLUSION
Combined treatment with Qinghe dispel paralysis soup can better promote the recovery of balance, improve motor ability, and reduce the development of inflammation in the organism, with high safety and effectiveness.
目的
探讨清热除痹汤对膝关节骨关节炎患者膝关节运动功能及机体炎症水平的影响。
方法
选取 2020 年 1 月至 2021 年 5 月收治的膝骨关节炎患者 116 例，随机分为 2 组，对照组 58 例给予洛索洛芬钠分散片治疗，实验组 58 例在对照组基础上给予清热除痹汤治疗，分析患者平衡能力、步态参数变化、VAS、JOA、AIMS2-SF 量表评估、血清指标，检测两种治疗方案的治疗效果。
结果
治疗后实验组前-后轴、左-右轴、A2-A6、A4-A8、环轴低于对照组（<0.05）；实验组步长高于对照组（<0.05），步速、双支撑相、步宽比较差异无统计学意义（>0.05），但两组均较治疗前改善（<0.05）；实验组 VAS 评分低于对照组，实验组 VAS 评分低于对照组，JOA 和 AIMS2-SF 评分高于对照组（<0.05）；实验组 TIMP-1 水平高于对照组，治疗后实验组 TNF-、TLR4、MMP-3、IL-1 水平低于对照组（<0.05）；治疗过程中两组不良反应发生率比较差异无统计学意义（>0.05），实验组有效率高于对照组（<0.05）。
结论
清热除痹汤联合治疗能更好地促进平衡恢复，提高运动能力，减少机体炎症的发展，具有较高的安全性和有效性。
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