2004 年至 2022 年骨关节炎自噬的知识图谱：文献计量分析。

BACKGROUND: Autophagy in osteoarthritis (OA) has become an active area of research with substantial value and potential. Nevertheless, few bibliometric studies have systematically analyzed the available research in the field. The main goal of this study was to map the available literature on the role of autophagy in OA and identify global research hotspots and trends. METHODS: The Web of Science Core Collection and Scopus databases were interrogated for studies of autophagy in OA published between 2004 and 2022. Microsoft Excel, VOSviewer and CiteSpace software were used to analyze and visualize the number of publications and associated citations, and reveal global research hotspots and trends in the autophagy in OA field. RESULTS: 732 outputs published by 329 institutions from 55 countries/regions were included in this study. From 2004 to 2022, the number of publications increased. China produced the most publications (n=456), prior to the USA (n=115), South Korea (n=33), and Japan (n=27). Scripps Research Institute (n=26) was the most productive institution. Martin Lotz (n=30) was the highest output author, while Caramés B (n=302) was the highest output author. was the most prolific and most co-cited journal. Currently, the autophagy in OA research hotspots include chondrocyte, transforming growth factor beta 1 (TGF-β1), inflammatory response, stress, and mitophagy. The emerging research trends in this field are AMPK, macrophage, senescence, apoptosis, tougu xiaotong capsule (TXC), green tea extract, rapamycin, and dexamethasone. Novel drugs targeting specific molecule such as TGF-β and AMPK have shown therapeutic potential but are still in the preclinical stage of development. CONCLUSIONS: Research on the role of autophagy in OA is flourishing. Martin Lotz, Beatriz Caramés, and have made outstanding contributions to the field. Prior studies of OA autophagy mainly focused on mechanisms underlying OA and autophagy, including AMPK, macrophages, TGF-β1, inflammatory response, stress, and mitophagy. Emerging research trends, however, are centered around the relationship between autophagy, apoptosis, and senescence, as well as drug candidates such as TXC and green tea extract. The development of new targeted drugs that enhance or restore autophagic activity is a promising strategy for the treatment of OA.

背景：自噬在骨关节炎（OA）中的作用已成为一个活跃的研究领域，具有重要的价值和潜力。然而，很少有文献计量学研究系统地分析了该领域现有的研究。本研究的主要目的是绘制自噬在 OA 中的作用的现有文献图谱，并确定全球研究热点和趋势。

方法：在 2004 年至 2022 年期间，通过 Web of Science 核心合集和 Scopus 数据库检索了自噬在 OA 中的研究文献。使用 Microsoft Excel、VOSviewer 和 CiteSpace 软件分析和可视化出版物数量和相关引文，揭示自噬在 OA 领域的全球研究热点和趋势。

结果：本研究共纳入 329 个机构发表的 732 项成果，来自 55 个国家/地区。自 2004 年至 2022 年，出版物数量不断增加。中国发表的论文数量最多（n=456），其次是美国（n=115）、韩国（n=33）和日本（n=27）。斯克里普斯研究所（n=26）是最具生产力的机构。Martin Lotz（n=30）是最高产的作者，而 Caramés B（n=302）是最高产的作者。是最有影响力和最常被引用的期刊。目前，OA 自噬研究的热点包括软骨细胞、转化生长因子-β1（TGF-β1）、炎症反应、应激和线粒体自噬。该领域新兴的研究趋势包括 AMPK、巨噬细胞、衰老、细胞凋亡、透骨消痛胶囊（TXC）、绿茶提取物、雷帕霉素和地塞米松。针对 TGF-β和 AMPK 等特定分子的新型药物显示出治疗潜力，但仍处于临床前开发阶段。

结论：自噬在 OA 中的作用的研究正在蓬勃发展。Martin Lotz、Beatriz Caramés 和对该领域做出了杰出贡献。先前关于 OA 自噬的研究主要集中在 OA 和自噬的机制上，包括 AMPK、巨噬细胞、TGF-β1、炎症反应、应激和线粒体自噬。然而，新兴的研究趋势集中在自噬、细胞凋亡和衰老之间的关系以及 TXC 和绿茶提取物等药物候选物上。开发增强或恢复自噬活性的新型靶向药物是治疗 OA 的一种有前途的策略。