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多发性内分泌腺瘤病2型:概述

Multiple endocrine neoplasia 2: an overview.

作者信息

Saravana-Bawan B, Pasternak J D

机构信息

University Health Network, University of Toronto, Toronto, ON, Canada.

Section Head, Endocrine Surgery and Oncology, Division of General Surgery, Sprott Department of Surgery, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada.

出版信息

Ther Adv Chronic Dis. 2022 Feb 25;13:20406223221079246. doi: 10.1177/20406223221079246. eCollection 2022.

DOI:10.1177/20406223221079246
PMID:35237400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8882936/
Abstract

This review article discusses the diagnosis and treatment of patients with multiple endocrine neoplasia type 2 (MEN2). The most common tumors associated with MEN2 are those of the parathyroid, thyroid, and adrenal glands. Additional manifestations include characteristic clinical phenotypes or features as described in the article. This review provides an overview of clinical manifestations, screening, diagnosis, treatment, and surveillance of patients with MEN2.

摘要

这篇综述文章讨论了2型多发性内分泌腺瘤病(MEN2)患者的诊断和治疗。与MEN2相关的最常见肿瘤是甲状旁腺、甲状腺和肾上腺的肿瘤。其他表现包括本文所述的特征性临床表型或特征。本综述概述了MEN2患者的临床表现、筛查、诊断、治疗和监测。

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本文引用的文献

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Similar Stage-dependent Survival and Outcome in Sporadic and Hereditary Medullary Thyroid Carcinoma.散发性与遗传性髓样甲状腺癌的相似阶段依赖性生存和结局。
J Clin Endocrinol Metab. 2021 Aug 18;106(9):e3582-e3591. doi: 10.1210/clinem/dgab326.
2
Hereditary Medullary Thyroid Carcinoma: Genotype, Phenotype and Outcomes in a North Indian Cohort.遗传性髓样甲状腺癌:一个北印度队列的基因型、表型和结局。
World J Surg. 2021 Jun;45(6):1785-1793. doi: 10.1007/s00268-021-05993-w. Epub 2021 Feb 19.
3
Roles of the Proto-oncogene in Cancer and Development.原癌基因在癌症与发育中的作用。
JMA J. 2020 Jul 15;3(3):175-181. doi: 10.31662/jmaj.2020-0021. Epub 2020 Jul 7.
4
Predicting Outcomes in Sporadic and Hereditary Medullary Thyroid Carcinoma over Two Decades.预测二十年来散发性和遗传性髓样甲状腺癌的结局。
Thyroid. 2021 Apr;31(4):616-626. doi: 10.1089/thy.2020.0167. Epub 2020 Nov 25.
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Efficacy of Selpercatinib in -Altered Thyroid Cancers.塞尔帕替尼在改变的甲状腺癌中的疗效。
N Engl J Med. 2020 Aug 27;383(9):825-835. doi: 10.1056/NEJMoa2005651.
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100-Year evolution of precision medicine and surgery for multiple endocrine neoplasia type 2A.2A 型多发性内分泌腺瘤病的精准医学与手术的百年演进
Endocrine. 2020 May;68(2):368-376. doi: 10.1007/s12020-020-02232-5. Epub 2020 Feb 25.
7
Twenty-Five Years Experience on RET Genetic Screening on Hereditary MTC: An Update on The Prevalence of Germline RET Mutations.RET 基因遗传筛查在遗传性 MTC 中的 25 年经验:种系 RET 突变的流行率更新。
Genes (Basel). 2019 Sep 10;10(9):698. doi: 10.3390/genes10090698.
8
Pheochromocytoma and Paraganglioma.嗜铬细胞瘤和副神经节瘤。
N Engl J Med. 2019 Aug 8;381(6):552-565. doi: 10.1056/NEJMra1806651.
9
Survival and Long-Term Biochemical Cure in Medullary Thyroid Carcinoma in Denmark 1997-2014: A Nationwide Study.丹麦 1997-2014 年的甲状腺髓样癌的生存和长期生化治愈:一项全国性研究。
Thyroid. 2019 Mar;29(3):368-377. doi: 10.1089/thy.2018.0564. Epub 2019 Jan 31.
10
Prophylactic thyroidectomy in children with multiple endocrine neoplasia type 2.预防性甲状腺切除术在多发性内分泌肿瘤 2 型患儿中的应用。
Br J Surg. 2018 Sep;105(10):1319-1327. doi: 10.1002/bjs.10856. Epub 2018 Apr 17.