Department of Ophthalmology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Biomed Res Int. 2022 Feb 21;2022:6600788. doi: 10.1155/2022/6600788. eCollection 2022.
We aim to evaluate the clinical effect of combined topical 20% autologous serum eye drops (ASEs) along with silicone-hydrogel soft contact lenses (SCLs) in the treatment of chemical burn-induced bilateral corneal persistent epithelial defects (PEDs) and to review the literature of related studies.
From January 1, 2017, to December 31, 2019, we conducted a retrospective chart review of 8 patients with chemical burn-induced bilateral corneal PEDs who were unsuccessfully treated with conventional medical therapy and were then treated with combined topical 20% (v/v) ASEs and silicone-hydrogel CLs. The clinical effects and effectiveness of the combined treatment were evaluated.
The bilateral corneal PEDs healed in all sixteen eyes of the eight patients within 2 weeks. The patients did not report any discomfort associated with the combined treatment. Improved ocular comfort/visual acuity and decreased conjunctival injection correlated with healing. No recurrent corneal epithelial breakdown was noted during the 3-month posttreatment follow-up.
The combined treatment of silicone-hydrogel CLs and ASEs can help to stabilize the ocular surface and successfully treat chemical burn-induced bilateral corneal PEDs. It may be considered as an alternative treatment method for patients with bilateral chemical burn-induced corneal PEDs with potential corneal melting.
我们旨在评估联合局部 20%自体血清滴眼液（ASEs）与硅酮水凝胶软隐形眼镜（SCLs）治疗化学性烧伤引起的双侧角膜持续性上皮缺损（PEDs）的临床效果，并复习相关研究的文献。
自 2017 年 1 月 1 日至 2019 年 12 月 31 日，我们对 8 例因常规药物治疗失败而接受联合局部 20%（v/v）ASEs 和硅酮水凝胶 CLs 治疗的化学性烧伤引起的双侧角膜 PEDs 患者进行了回顾性病历审查。评估了联合治疗的临床效果和有效性。
8 例患者的 16 只眼的双侧角膜 PEDs 在 2 周内愈合。患者未报告与联合治疗相关的任何不适。眼部舒适度/视力改善和结膜充血减轻与愈合相关。在治疗后 3 个月的随访中，未观察到复发性角膜上皮破裂。
硅酮水凝胶 CLs 和 ASEs 的联合治疗可以帮助稳定眼表面，成功治疗化学性烧伤引起的双侧角膜 PEDs。对于有潜在角膜融化的双侧化学性烧伤引起的角膜 PEDs 患者，可考虑将其作为替代治疗方法。
