Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Korea.
Eye Contact Lens. 2011 Nov;37(6):370-3. doi: 10.1097/ICL.0b013e318233c9bb.
We investigated the utility of a combination of autologous serum eye drops and a silicone-hydrogel (SH) lens in the treatment of persistent epithelial defects (PEDs).
Eight patients who had distinct PED conditions were treated with 50% (v/v) autologous serum eye drops in combination with silicone hydrogel contact lenses and prospectively observed.
The pathogenesis of PEDs included Sjogren-type dry eye syndrome, graft-versus-host disease, toxic keratitis, limbal cell deficiency, superior limbic keratoconjunctivitis, and neurotrophic keratitis. The patients had PEDs for 90±81.76 days (range: 30-240 days). Before the initiation of the combined treatment, three patients had already been unsuccessfully treated with SH lenses, and five patients had received serum eye drops alone. The PEDs of the eight eyes healed after a treatment period of 11.8±4.9 days. No visible deposits were noted on the surface of any contact lens.
These findings demonstrate that the combination of an SH lens and serum eye drops may be effective in the treatment of intractable PEDs.
我们研究了自体血清滴眼液和硅酮水凝胶（SH）镜片联合应用于持续性上皮缺损（PED）治疗的效果。
对 8 例具有不同 PED 情况的患者采用 50%（v/v）自体血清滴眼液联合硅酮水凝胶隐形眼镜进行治疗，并进行前瞻性观察。
PED 的发病机制包括 Sjogren 型干燥综合征、移植物抗宿主病、中毒性角膜炎、角膜缘细胞缺乏、上边缘性角结膜炎和神经营养性角膜炎。患者的 PED 持续时间为 90±81.76 天（范围：30-240 天）。在开始联合治疗之前，有 3 名患者已经接受 SH 镜片治疗但未成功，5 名患者单独接受血清滴眼剂治疗。8 只眼的 PED 在 11.8±4.9 天的治疗后愈合。未观察到任何隐形眼镜表面有明显的沉积物。
这些发现表明，SH 镜片和血清滴眼剂联合应用可能对治疗难治性 PED 有效。
