Habota Tina, Sandu Anca-Larisa, Waiter Gordon D, McNeil Christopher J, Steele J Douglas, Macfarlane Jennifer A, Whalley Heather C, Valentine Ruth, Younie Dawn, Crouch Nichola, Hawkins Emma L, Hirose Yoriko, Romaniuk Liana, Milburn Keith, Buchan Gordon, Coupar Tessa, Stirling Mairi, Jagpal Baljit, MacLennan Beverly, Priba Lucasz, Harris Mathew A, Hafferty Jonathan D, Adams Mark J, Campbell Archie I, MacIntyre Donald J, Pattie Alison, Murphy Lee, Reynolds Rebecca M, Elliot Rebecca, Penton-Voak Ian S, Munafò Marcus R, Evans Kathryn L, Seckl Jonathan R, Wardlaw Joanna M, Lawrie Stephen M, Haley Christopher S, Porteous David J, Deary Ian J, Murray Alison D, McIntosh Andrew M
University of Aberdeen, Aberdeen, UK.
University of Dundee, Dundee, UK.
Wellcome Open Res. 2021 Jul 16;4:185. doi: 10.12688/wellcomeopenres.15538.2. eCollection 2019.
STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures relevant to the study of depression, psychological resilience, and cognition. In addition, routinely collected historic NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.
纵向分层抗逆力与抑郁（STRADL）研究是一项基于“苏格兰世代：苏格兰家庭健康研究”（GS:SFHS）资源开展的人群研究。STRADL的目的是利用详细的临床、认知和脑成像评估，根据病因对重度抑郁症（MDD）进行亚型分类。GS:SFHS为研究复杂的基因-环境相互作用提供了重要契机，它将与现有数据集建立联系，并纳入两个纵向出生队列的早期生活变量。具体而言，STRADL的数据收集包括：社会经济和生活方式变量；身体测量；评估抗逆力、早期生活逆境、人格、心理健康和情绪障碍终生史的问卷数据；实验室样本；认知测试；以及脑磁共振成像。部分问卷和认知数据在2006年至2011年的GS:SFHS基线评估中首次进行评估，从而提供了与抑郁症、心理抗逆力和认知研究相关的纵向测量数据。此外，常规收集的历史国民保健服务（NHS）数据和早期生活变量与STRADL数据相关联，进一步提供了纵向分析的机会。招募工作已经完成，我们已征得1188名参与者的同意并对其进行了测试。
