The Department of Obstetrics and Gynaecology, The University of Auckland, Auckland, New Zealand.
Department of Gynaecology, The Hospital of Obstetrics and Gynaecology, Fudan University, Shanghai, China.
Biosci Rep. 2022 Mar 31;42(3). doi: 10.1042/BSR20212192.
The latest evidence suggests that type 2 endometrial cancer may not be completely oestrogen-independent, indicating that the status of hormonal change may not be associated with the traditional classification of endometrial cancer, including the histological subtypes. However, this has not been investigated. Menopause is commonly considered a state of hormonal change in women. In the present study, we investigated the association of menopause with the histological types of endometrial cancer. Data on the histological type, menopause status at diagnosis, age at diagnosis, parity, body mass index (BMI), and overall survival rate from 2122 cases were collected. The difference in risk in developing type 1 or type 2 endometrial cancer between premenopausal and postmenopausal patients was 5.457%. A statistical difference in the association of menopause with the histological types between the two groups was seen in endometrioid and serous carcinoma, with a risk difference of 5.6 or 3.8%. A statistical difference in the association of menopause with parity between the groups was only seen in endometrioid and adenosquamous carcinoma, with a risk difference of 7.1 or 3.7%. However, BMI was not associated with histological type and the overall survival rate was not associated with menopause (P=0.764). We reported a relatively small difference in the association of menopause with type 1 or type 2, or the histological types of endometrial cancer. The survival rate was not associated with menopause. Our study suggests that menopause status at diagnosis was not strongly associated with the histological subtypes of endometrial cancer.
最新证据表明，2 型子宫内膜癌可能并非完全依赖于雌激素，这表明激素变化的状态可能与子宫内膜癌的传统分类无关，包括组织学亚型。然而，这一点尚未得到调查。绝经通常被认为是女性激素变化的状态。在本研究中，我们调查了绝经与子宫内膜癌组织学类型之间的关联。收集了 2122 例患者的组织学类型、诊断时的绝经状态、诊断时的年龄、产次、体重指数（BMI）和总生存率数据。绝经前和绝经后患者患 1 型或 2 型子宫内膜癌的风险差异为 5.457%。两组之间绝经与组织学类型之间的关联存在统计学差异，在子宫内膜样癌和浆液性癌中，风险差异为 5.6 或 3.8%。仅在子宫内膜样癌和腺鳞癌中，绝经与产次之间的关联存在统计学差异，风险差异为 7.1 或 3.7%。然而，BMI 与组织学类型无关，总生存率与绝经无关（P=0.764）。我们报告了绝经与 1 型或 2 型或子宫内膜癌组织学类型之间的关联存在相对较小的差异。生存率与绝经无关。我们的研究表明，诊断时的绝经状态与子宫内膜癌的组织学亚型没有很强的关联。
