Aragno Elena, Fagiolini Andrea, Cuomo Alessandro, Paschetta Elena, Maina Giuseppe, Rosso Gianluca
Department of Neurosciences "Rita Levi Montalcini", University of Torino, Turin, Italy.
Department of Molecular Medicine, University of Siena, Siena, Italy.
Arch Womens Ment Health. 2022 Apr;25(2):257-266. doi: 10.1007/s00737-022-01217-9. Epub 2022 Mar 2.
Several lines of research suggest that reproductive-related hormonal events may affect the course of bipolar disorder in some women. However, data on associations between bipolar disorder and menarche, menstrual cycle, and menopause are mixed. This article reviews the literature on the potential effects of menarche, menstrual cycle, and menopause on bipolar disorder.A narrative review of published articles on bipolar disorder and menstrual cycle events was conducted. The primary outcome assessed was the impact of menarche, menstrual cycle and menopause on the course of bipolar illness. Databases searched were PubMed, Ovid, Scopus, PsycINFO, Medline, and Cochrane Libraries from inception to August 2021.Twenty-two studies were identified and included in the narrative synthesis. Research suggested that a subset of women with bipolar disorder are vulnerable to the impact of menstrual cycle events. Menarche seems to be associated with age at onset of bipolar illness especially in case of bipolar disorder type I and the specific age at menarche may predict some clinical features of the disorder. Menstrual cycle likely affects the course of bipolar disorder but the pattern of mood variability is not clear. Menopause appears to be not only a period of vulnerability to mood alteration, especially depressive episodes, and impairment of quality of life, but also a potential trigger of bipolar illness onset.The impact of menarche, menstrual cycle, and menopause on bipolar disorder is largely understudied. Preliminary evidence suggests that a subset of women with bipolar disorder may have their mood shifts affected by menstrual cycle events, with different patterns depending on the type of bipolar disorder also. Further researches are needed to deep the impact of menarche, menstrual cycle, and menopause on bipolar illness.
多项研究表明，与生殖相关的激素事件可能会影响一些女性双相情感障碍的病程。然而，关于双相情感障碍与初潮、月经周期和绝经之间关联的数据并不一致。本文综述了有关初潮、月经周期和绝经对双相情感障碍潜在影响的文献。
对已发表的关于双相情感障碍和月经周期事件的文章进行了叙述性综述。评估的主要结果是初潮、月经周期和绝经对双相情感障碍病程的影响。检索的数据库包括从建库至2021年8月的PubMed、Ovid、Scopus、PsycINFO、Medline和Cochrane图书馆。
共识别出22项研究并纳入叙述性综合分析。研究表明，一部分双相情感障碍女性易受月经周期事件的影响。初潮似乎与双相情感障碍的发病年龄有关，尤其是在I型双相情感障碍中，特定的初潮年龄可能预示该疾病的一些临床特征。月经周期可能会影响双相情感障碍的病程，但情绪波动模式尚不清楚。绝经似乎不仅是一个易出现情绪改变（尤其是抑郁发作）和生活质量受损的时期，也是双相情感障碍发病的一个潜在触发因素。
初潮、月经周期和绝经对双相情感障碍的影响在很大程度上尚未得到充分研究。初步证据表明，一部分双相情感障碍女性的情绪波动可能会受到月经周期事件的影响，且根据双相情感障碍的类型不同，模式也有所不同。需要进一步研究来深入了解初潮、月经周期和绝经对双相情感障碍的影响。
