Clinical and Health Psychology Research Initiative (CaHPRI), School of Psychology, Western Sydney University, Australia; Translational Health Research Institute, Western Sydney University, Australia.
Translational Health Research Institute, Western Sydney University, Australia.
Maturitas. 2021 Jan;143:72-77. doi: 10.1016/j.maturitas.2020.09.002. Epub 2020 Sep 16.
The menopause transition may be associated with increased symptoms for women living with bipolar disorder; however, few have explored how this compares with other reproductive phases. The aim of this study was to compare women at reproductive, menopause transition and post-menopause phases on measures of quality of life and psychological symptoms associated with bipolar disorder.
Women with bipolar disorder took part in a large international survey conducted online and were categorised into reproductive stages using the STRAW and Monash criteria. The 498 participants were divided into three groups: 202 (41%) in the reproductive age group, 101 (20%) in the menopause transition group and 195 (39%) in the post-menopause group.
The Menopause Rating Scale (MRS), the Depression Anxiety and Stress Scales - 21 (DASS-21), the Altman Mania Rating Scale (ASRM) and the Bipolar Disorder Quality of Life scale (BD-QoL).
BD-QoL scores were significantly lower in the menopause transition group than in the other groups and that group was more likely to report being constantly depressed over the past year than the other groups. Anxiety was significantly higher in the menopause transition and post-menopause groups compared with the reproductive age group.
Quality of life and depression are impacted by the menopause transition for women with bipolar disorder. However, anxiety may be a clinical issue for women in both the post-menopause and the menopause transition phases. Research is needed to determine how symptoms vary across the reproductive life cycle for women with bipolar disorder and if targeted treatments may assist.
更年期过渡可能与患有双相情感障碍的女性的症状增加有关；然而，很少有人探讨这与其他生殖阶段相比如何。本研究旨在比较处于生殖、更年期过渡和绝经后阶段的女性在与双相情感障碍相关的生活质量和心理症状方面的差异。
患有双相情感障碍的女性参加了一项大型国际在线调查，并根据 STRAW 和 Monash 标准将其分为生殖阶段。498 名参与者分为三组：202 名（41%）处于生殖年龄组，101 名（20%）处于更年期过渡组，195 名（39%）处于绝经后组。
更年期评定量表（MRS）、抑郁焦虑和压力量表-21（DASS-21）、阿尔特曼躁狂评定量表（ASRM）和双相情感障碍生活质量量表（BD-QoL）。
更年期过渡组的 BD-QoL 评分明显低于其他组，且该组在过去一年中经常感到抑郁的可能性高于其他组。更年期过渡组和绝经后组的焦虑评分明显高于生殖年龄组。
更年期过渡会影响患有双相情感障碍的女性的生活质量和抑郁情况。然而，焦虑可能是绝经后和更年期过渡阶段女性的临床问题。需要研究确定双相情感障碍女性在生殖生命周期中症状如何变化，以及是否需要针对性治疗。
