Cardiff School of Biosciences, Cardiff University, Cardiff, UK.
Methods Mol Biol. 2022;2419:57-72. doi: 10.1007/978-1-0716-1924-7_4.
Although in vitro model systems are useful for investigation of atherosclerosis-associated processes, they represent simplification of complex events that occur in vivo, which involve interactions between many different cell types together with their environment. The use of animal model systems is important for more in-depth insights of the molecular mechanisms underlying atherosclerosis and for identifying potential targets for agents that can prevent plaque formation and even reverse existing disease. This chapter will provide a survey of such animal models and associated techniques that are routinely used for research of atherosclerosis in vivo.
虽然体外模型系统对于研究动脉粥样硬化相关过程非常有用，但它们代表了体内复杂事件的简化，这些事件涉及许多不同细胞类型及其环境之间的相互作用。动物模型系统的使用对于深入了解动脉粥样硬化的分子机制以及鉴定能够预防斑块形成甚至逆转现有疾病的潜在药物靶点非常重要。本章将介绍常用于体内动脉粥样硬化研究的此类动物模型和相关技术。
