Khannanova A N, Nabiev Sh R, Fominykh V V, Golyakhovskaya A Ya, Brylev L V
Mental Health Clinic No. 4 named after P.B. Gannushkin, Moscow, Russia.
Buyanov Moscow City Clinical Hospital, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(1. Vyp. 2):49-54. doi: 10.17116/jnevro202212201249.
Currently there is a new concept of «molecular neuropsychiatry» which aim is identification of biomarkers and biological substrates for mental disorders. Autoimmune encephalitis can start with psychiatric symptoms in 60% of cases. In this article we described a clinical case of a patient, 31 years old, with GABAb-associated AE started with acute polymorphic psychosis. AE was diagnosed and treated in time with a good clinical effect. According to the frequency of psychiatric symptoms in AE patients it should be reasonable to include antineuronal test in CSF and serum in patients with first acute psychosis if «red flags» or atypical course of the disease.
目前有一种“分子神经精神病学”的新概念,其目的是识别精神障碍的生物标志物和生物学底物。60%的自身免疫性脑炎病例可始于精神症状。在本文中,我们描述了一例31岁患者的临床病例,该患者患有与GABAb相关的自身免疫性脑炎,首发为急性多形性精神病。自身免疫性脑炎得到及时诊断和治疗,临床效果良好。根据自身免疫性脑炎患者精神症状的发生频率,如果存在“警示信号”或疾病过程不典型,对于首发急性精神病患者,在脑脊液和血清中进行抗神经元检测是合理的。