Alliance for Benzodiazepine Best Practices, 3221 NE 30th Ave, Portland, OR, 97212, USA.
Adv Ther. 2022 May;39(5):1871-1880. doi: 10.1007/s12325-022-02055-y. Epub 2022 Mar 3.
Although benzodiazepines have been used for 6 decades, many questions remain unanswered by research. The lived experiences of those adversely affected long term can provide insights into how these agents might be more thoughtfully prescribed. Here, perspectives of one such experience encompassing benzodiazepine initiation, ongoing use with adverse consequences and difficult discontinuation are presented through the eyes of an affected individual and a clinician. This experience highlights the importance of limited initiation and duration of use (2-4 weeks) as well as a supported, slow tapering process led by patients. Because researched evidence about deprescribing benzodiazepines is insufficient and because individual experiences vary so widely, it is the patient's expertise-that of her or his lived experience-that should assume a primary role in determining the course and pace of discontinuing these medications.
尽管苯二氮䓬类药物已经使用了 60 年,但研究仍有许多未解之谜。长期受其负面影响的人的生活经历可以为更慎重地开具这些药物提供一些见解。在这里,通过一位受影响的个体和一位临床医生的视角,呈现了一个涵盖苯二氮䓬类药物起始使用、持续使用产生不良后果和停药困难的经历。这一经历强调了有限的起始和使用时间(2-4 周)以及由患者主导的支持性、缓慢的减量过程的重要性。由于关于苯二氮䓬类药物停药的研究证据不足,而且个体经历差异很大,因此患者的专业知识——即她或他的生活经历——应该在确定停止这些药物的过程和速度方面发挥主要作用。