LiPuma J P, Bryan P J, Butler H E, Resnick M I
Urol Clin North Am. 1986 Aug;13(3):531-50.
MRI is in its infancy as a clinical imaging tool. It is undergoing intensive investigation in various areas of the body. Evaluation of the brain and spine is superb, and in some areas of the brain, like the posterior fossa, it is thought to be superior to CT. Evolving indications for body scanning include staging of pelvic malignancies, evaluation of liver malignancy, evaluation and staging of musculoskeletal problems, and, to a lesser degree, staging of renal malignancies and evaluation of vascular disease. The main problem in body imaging stems from image degradation because of respiratory motion that is transmitted to upper abdominal organs. Respiratory gating of image acquisition or utilization of short heavily T1-weighted pulse sequences will likely overcome this problem in due time. Minimizing motion artifact will make MR images comparable to, if not better than, CT images with regard to transverse anatomic display, and MR images have the added advantage of multiplanar scanning, which can be done directly, without need of additional computer reconstruction time and without having to move the patient. The second major problem in MRI is the lack of understanding of equipment potential. Unlike conventional radiography and CT, in which the behavior of the X-ray beam is understood with regard to image formation, in MRI new parameters are used to generate images. As stated earlier, MR signal intensity is due to hydrogen concentration, T1 and T2 relaxation times of the tissue, and flow of protons through the imaged volume. How these factors are weighted depends on pulse sequence selection, and thus image contrast and information content of the scans change. On the surface, these images display anatomic information as do other imaging modalities, but manipulation of pulse sequences may ultimately lead to the ability to demonstrate physiologic and chemical parameters previously unavailable in imaging. Current research is geared to help extract this data by testing new pulse sequences, using different types of receiver RF coils, and using MR-specific contrast materials. Minor MRI problems such as long scan times are being dealt with to decrease time to an acceptable length. The nonvisualization of soft tissue calcifications will probably remain a problem that may have to be weighed against other known advantages. At this time further research and clinical experience are the key to what is needed in MRI, to gain further knowledge with regard to imaging physiologic phenomena, such as flow and spectroscopy, and possibly to monitor the chemical basis of disease.(ABSTRACT TRUNCATED AT 400 WORDS)
作为一种临床成像工具,磁共振成像(MRI)尚处于起步阶段。它正在身体的各个领域接受深入研究。对大脑和脊柱的评估效果极佳,在大脑的某些区域,如后颅窝,人们认为它优于CT。不断发展的身体扫描适应证包括盆腔恶性肿瘤的分期、肝脏恶性肿瘤的评估、肌肉骨骼问题的评估和分期,以及在较小程度上肾恶性肿瘤的分期和血管疾病的评估。身体成像的主要问题源于呼吸运动导致的图像退化,这种运动传递到上腹部器官。图像采集的呼吸门控或使用短的重T1加权脉冲序列可能会在适当的时候克服这个问题。将运动伪影降至最低将使MR图像在横向解剖显示方面与CT图像相当,甚至可能更好,而且MR图像还具有多平面扫描的额外优势,无需额外的计算机重建时间,也无需移动患者即可直接进行。MRI的第二个主要问题是对设备潜力缺乏了解。与传统放射摄影和CT不同,在传统放射摄影和CT中,人们了解X射线束在图像形成方面的行为,而在MRI中,使用新的参数来生成图像。如前所述,MR信号强度取决于氢浓度、组织的T1和T2弛豫时间以及质子通过成像体积的流动。这些因素如何加权取决于脉冲序列的选择,因此扫描的图像对比度和信息含量会发生变化。从表面上看,这些图像与其他成像方式一样显示解剖信息,但脉冲序列的操作最终可能会导致能够展示以前在成像中无法获得的生理和化学参数。目前的研究旨在通过测试新的脉冲序列、使用不同类型的接收射频线圈以及使用MR特异性对比剂来帮助提取这些数据。正在处理诸如扫描时间长等较小的MRI问题,以将时间缩短到可接受的长度。软组织钙化的不可见性可能仍然是一个问题,可能需要与其他已知优势进行权衡。目前,进一步的研究和临床经验是MRI所需的关键,以获得关于成像生理现象(如血流和光谱学)的更多知识,并可能监测疾病的化学基础。(摘要截取自400字)