University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane & Women's Hospital, Herston, Queensland, Australia.
School of Psychology.
Cogn Behav Neurol. 2022 Mar 3;35(1):1-13. doi: 10.1097/WNN.0000000000000292.
The Attention Network Test (ANT) is a well-established measure of efficiency for the alerting, orienting, and executive attentional networks. However, its novel application in Parkinson disease (PD) and Lewy body dementia (LBD) research more broadly has yet to be evaluated systematically.
To compare and consolidate the outcomes of studies reporting use of the ANT in PD and LBD groups and to identify the methodological considerations for the conduct of such studies.
We performed a systematic literature search for articles exploring attention in PD and LBD groups using the ANT. We excluded articles on the basis of irrelevant scope, non-English, and groups other than PD and LBD. Once the full text articles were identified, we extracted the data and assessed the studies' quality.
The final sample included 16 articles ranging from low to moderate quality. Behavioral findings suggested a general slowing of responses yet preserved accuracy from the PD group compared with controls. Overall, the evidence was inconclusive regarding the state of the alerting network in the PD and LBD groups, mostly supportive of an intact orienting network, and strongly suggestive of an impaired executive network. Differences in sample stratification, patient symptomatology, and dopaminergic medication levels were identified as influential factors in the attentional results across studies.
Although sparse, the existing evidence indicates that the ANT is a viable option for measuring attention in PD; it can also be harnessed to explore the impact of symptoms and medications on attentional networks in PD and LBD groups.
注意网络测试（ANT）是一种成熟的警觉、定向和执行注意网络效率的测量方法。然而，它在帕金森病（PD）和路易体痴呆（LBD）研究中的新应用尚未得到系统评估。
比较和整合使用 ANT 评估 PD 和 LBD 患者注意力的研究结果，并确定此类研究的方法学注意事项。
我们系统地搜索了使用 ANT 评估 PD 和 LBD 患者注意力的文章。我们根据不相关的范围、非英语以及非 PD 和 LBD 患者的组别排除了文章。一旦确定了全文文章，我们就提取了数据并评估了研究的质量。
最终样本包括 16 篇质量从低到中等的文章。行为学发现表明 PD 组的反应速度普遍较慢，但准确性与对照组相当。总体而言，关于 PD 和 LBD 组警觉网络状态的证据尚无定论，大多支持定向网络完好，强烈提示执行网络受损。研究中发现，样本分层、患者症状和多巴胺能药物水平的差异是影响注意力结果的重要因素。
尽管证据有限，但现有证据表明 ANT 是评估 PD 患者注意力的可行选择；它也可以用于探索症状和药物对 PD 和 LBD 患者注意力网络的影响。
