The First People's Hospital of Jinan City, Department of Surgery - Jinan, China.
The First Affiliated Hospital of Shandong First Medical University, Department of Medical Ultrasound - Jinan, China.
Rev Assoc Med Bras (1992). 2022 Feb;68(2):170-175. doi: 10.1590/1806-9282.20210822.
A growing volume of literature has suggested long noncoding RNAs (lncRNAs) as important players in tumor progression. In this study, we aimed to investigate the expression and prognostic value of lncRNA LINC00173 (LINC00173) in melanoma.
LINC00173 expression was measured in 163 paired cancerous and noncancerous specimen samples by real-time polymerase chain reaction. The correlations between LINC00173 expression with clinicopathological characteristics and prognosis were analyzed by chi-square test, log-rank test, and multivariate survival analysis. Receiver-operating characteristic curves were used for the assessment of the diagnostic value of LINC00173 for melanoma patients.
The expression level of LINC00173 in melanoma specimens was distinctly higher than that in adjacent non-neoplasm specimens (p<0.01). Besides, LINC00173 was expressed more frequently in patients with advanced melanoma than in patients with early melanoma. Multivariate assays confirmed that LINC00173 expression level was an independent prognostic predictor of melanoma patients (p<0.05).
Our data indicated that LINC00173 expression could serve as an unfavorable prognostic biomarker for melanoma patients.
越来越多的文献表明长非编码 RNA（lncRNA）在肿瘤进展中起着重要作用。本研究旨在探讨 lncRNA LINC00173（LINC00173）在黑色素瘤中的表达及预后价值。
采用实时聚合酶链反应检测 163 对癌组织及癌旁非肿瘤组织中 LINC00173 的表达情况。采用卡方检验、log-rank 检验及多因素生存分析分析 LINC00173 表达与临床病理特征及预后的相关性。采用受试者工作特征曲线评估 LINC00173 对黑色素瘤患者的诊断价值。
与癌旁非肿瘤组织相比，黑色素瘤组织中 LINC00173 的表达水平明显升高（p<0.01）。此外，LINC00173 在晚期黑色素瘤患者中的表达频率高于早期黑色素瘤患者。多因素分析证实 LINC00173 表达水平是黑色素瘤患者的独立预后预测因子（p<0.05）。
我们的数据表明 LINC00173 的表达可以作为黑色素瘤患者不良预后的生物标志物。
