产自埃塞俄比亚亚种 Besama abyssinica 的叶子的细胞毒素化合物。
Cytotoxic compounds from the leaf of Bersama abyssinica subspecies abyssinica.
机构信息
Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Straße 6, 44227, Dortmund, Germany; Department of Chemistry, Faculty of Sciences, Egerton University, P.O. Box 536, 20115, Egerton, Kenya.
Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Straße 6, 44227, Dortmund, Germany; Department of Chemistry, Addis Ababa University, P.O. Box 33658, Addis Ababa, Ethiopia.
出版信息
Phytochemistry. 2022 Jun;198:113153. doi: 10.1016/j.phytochem.2022.113153. Epub 2022 Mar 1.
From the leaves of Kenyan medicinal plant Bersama abyssinica Subspecies abyssinica, four previously undescribed compounds namely, three bufadienolides, 10β-formylpaulliniogenin B, 10β-formylpaulliniogenin A and 1β-acetoxy-3β,5β-dihydroxy-15-methoxy-16,19-dioxobufa-14(15),20,22-trienolide, and a phenolic compound 2,6,4'-trihydroxybenzophenone-4-O-(6‴-cinnamoyl)-β-D-glucoside were isolated together with four known compounds. The structural elucidation of the compounds was based on 1D and 2D NMR spectroscopy and HRMS data analyses. The relative configurations were defined by NOESY correlations. Cytotoxic activities on L929 and KB3.1 cell lines of the isolated compounds were investigated using MTT assay. The 1β-acetoxy-3β,5β-dihydroxy-15-methoxy-16,19-dioxobufa-14(15),20,22-trienolide showed significant cytotoxic activity against KB3.1 cell lines with IC of 3.9 ± 0.99 μM.
从肯尼亚药用植物 Bersama abyssinica Subspecies abyssinica 的叶子中，分离得到了四个以前未被描述的化合物，分别为：三种蟾蜍甾烯内酯，10β-甲酰巴利尼烯醇 B、10β-甲酰巴利尼烯醇 A 和 1β-乙酰氧基-3β,5β-二羟基-15-甲氧基-16,19-二氧代-14(15),20,22-三烯内酯，以及一种酚类化合物 2,6,4'-三羟基二苯甲酮-4-O-(6‴-肉桂酰)-β-D-葡萄糖苷。这些化合物的结构是基于 1D 和 2D NMR 光谱和 HRMS 数据分析确定的。相对构型是通过 NOESY 相关确定的。采用 MTT 法测定了分离得到的化合物对 L929 和 KB3.1 细胞系的细胞毒性活性。1β-乙酰氧基-3β,5β-二羟基-15-甲氧基-16,19-二氧代-14(15),20,22-三烯内酯对 KB3.1 细胞系表现出显著的细胞毒性活性，IC 为 3.9±0.99μM。
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