从杠柳的根和根茎中提取的新型细胞毒素杠柳毒苷
New cytotoxic bufadienolides from the roots and rhizomes of Franch.
机构信息
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, China.
College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
出版信息
Nat Prod Res. 2020 Apr;34(7):950-957. doi: 10.1080/14786419.2018.1543687. Epub 2018 Dec 27.
Three new bufadienolides 14, 16-dihydroxy-3-[-D-glucopyranosyl-(1→6)-(-D-glucopyranosyl)oxy]-5-bufa-20, 22-dienolide (), 14-hydroxy-3-[-D-glucopyranosyl-(1→4)-(-D-glucopyranosyl)oxy]-5-bufa-20, 22-dienolide () and hellebrigenin-3---D-glucosyl-(1→4)--D-glucoside (), together with eight known bufadienolides (-) were isolated from the roots and rhizomes of . Their structures were elucidated by extensive spectroscopic methods and acid hydrolysis. Compounds - were evaluated for their cytotoxic activity against HCT116, A549 and HepG2 tumor cell lines. Compound exhibited moderate cytotoxicity against HepG2 cells with IC value of 15.1 ± 1.72 μM. Compounds and exhibited moderate cytotoxicity against HCT116 cells with IC values of 15.12 ± 0.58 μM and 13.17 ± 2.34 μM, respectively.
从杠柳的根和根茎中分离得到了三个新的蟾毒内酯化合物 14,16-二羟基-3-[-D-吡喃葡萄糖基-(1→6)-(-D-吡喃葡萄糖基)氧基]-5-蟾蜍二烯醇内酯 (), 14-羟基-3-[-D-吡喃葡萄糖基-(1→4)-(-D-吡喃葡萄糖基)氧基]-5-蟾蜍二烯醇内酯 () 和 hellebrigenin-3---D-吡喃葡萄糖基-(1→4)--D-吡喃葡萄糖苷 (), 同时还分离得到了八个已知的蟾毒内酯化合物 (-)。通过广泛的光谱方法和酸水解，确定了它们的结构。对 - 进行了细胞毒性活性评价，针对 HCT116、A549 和 HepG2 肿瘤细胞系。化合物 对 HepG2 细胞表现出中等的细胞毒性，IC 值为 15.1 ± 1.72 μM。化合物 对 HCT116 细胞表现出中等的细胞毒性，IC 值分别为 15.12 ± 0.58 μM 和 13.17 ± 2.34 μM。
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