Xu Jianda, Li Huan, Zheng Chong, Wang Bin, Shen Pengfei, Xie Zikang, Qu Yuxing
Department of Orthopaedics, Changzhou Traditional Chinese Medical Hospital, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, 25 North Heping Road, Changzhou, 213000, Jiangsu, China.
Department of bone and joint, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Suzhou University, Changzhou, 213003, China.
Arthroplasty. 2019 Nov 27;1(1):13. doi: 10.1186/s42836-019-0015-3.
Total knee arthroplasty (TKA) is regarded as the most effective surgery for patients with later-stage arthritis of the knee, but the postoperative pain management for functional improvement of the knew is still a challenging task. This review discusses the mechanism by which the selective cyclooxyenase-2 inhibitors, which reduce the peripheral and central sensitization, decrease pain after TKA. This review also covers the protocols, safety, efficacy, and progress of cyclooxyenase-2 inhibitors in pre-emptive analgesia.
全膝关节置换术（TKA）被认为是晚期膝关节炎患者最有效的手术，但膝关节功能改善的术后疼痛管理仍然是一项具有挑战性的任务。本综述讨论了选择性环氧化酶-2抑制剂减轻外周和中枢敏化从而降低TKA术后疼痛的机制。本综述还涵盖了环氧化酶-2抑制剂在超前镇痛中的方案、安全性、有效性及进展。
