Department of Pharmacology, ISF College of Pharmacy, Moga-142001, Punjab, India.
Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-144603, India.
Curr Drug Targets. 2022;23(9):913-923. doi: 10.2174/1389450123666220303094752.
Chemobrain is one of the major side effects of chemotherapy; despite increased research, the mechanisms underlying chemotherapy-induced cognitive changes remain unknown. Several possibly important candidate mechanisms have been identified and will be studied further in the future. Chemobrain is characterized by memory loss, cognitive impairment, difficulty in language, concentration, acceleration, and learning. The major characteristic of chemobrain is oxidative stress, mitochondrial dysfunction, immune dysregulation, hormonal alteration, white matter abnormalities, and DNA damage. Berberine (BBR) is an isoquinoline alkaloid extracted from various berberine species. BBR is a small chemical that easily passes the blood-brain barrier (BBB), making it useful for treating neurodegenerative diseases. Many studies on the pharmacology of BBR have been reported in the past. Furthermore, several clinical and experimental research indicates that BBR has a variety of pharmacological effects. So, in this review, we explore the pathogenesis of chemobrain and the neuroprotective potential of BBR against chemobrain. We also introduced the therapeutic role of BBR in various neurodegenerative and neurological diseases such as Alzheimer's, Parkinson's disease, mental depression, schizophrenia, anxiety, and also some stroke.
化疗脑是化疗的主要副作用之一；尽管研究有所增加，但化疗引起的认知变化的机制仍不清楚。已经确定了几个可能重要的候选机制，并将在未来进一步研究。化疗脑的特征是记忆力减退、认知障碍、语言、注意力、加速和学习困难。化疗脑的主要特征是氧化应激、线粒体功能障碍、免疫失调、激素改变、白质异常和 DNA 损伤。小檗碱（BBR）是从各种小檗属植物中提取的异喹啉生物碱。BBR 是一种小分子，很容易通过血脑屏障（BBB），使其可用于治疗神经退行性疾病。过去已经报道了许多关于 BBR 药理学的研究。此外，几项临床和实验研究表明，BBR 具有多种药理作用。因此，在这篇综述中，我们探讨了化疗脑的发病机制以及 BBR 对化疗脑的神经保护潜力。我们还介绍了 BBR 在各种神经退行性和神经疾病中的治疗作用，如阿尔茨海默病、帕金森病、精神抑郁、精神分裂症、焦虑症，以及一些中风。
