Department of Pharmaceutical Chemistry and Analysis, ISF College of Pharmacy Moga, Punjab, 142001, India.
Department of Pharmacology, ISF College of Pharmacy Moga, Punjab, 142001, India.
Curr Neuropharmacol. 2024;22(6):992-1015. doi: 10.2174/1570159X21666230105110834.
Neurodegenerative disorders (NDDs) are multifaceted complex disorders that have put a great health and economic burden around the globe nowadays. The multi-factorial nature of NDDs has presented a great challenge in drug discovery and continuous efforts are in progress in search of suitable therapeutic candidates. Nature has a great wealth of active principles in its lap that has cured the human population since ancient times. Natural products have revealed several benefits over conventional synthetic medications and scientists have shifted their vision towards exploring the therapeutic potentials of natural products in the past few years. The structural mimicking of natural compounds to endogenous ligands has presented them as a potential therapeutic candidate to prevent the development of NDDs. In the presented review, authors have summarized demographical facts about various NDDs including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and various types of sclerosis in the brain. The significant findings of new active principles of natural origin along with their therapeutic potentials on NDDs have been included. Also, a description of clinical trials and patents on natural products has been enlisted in this compilation. Although natural products have shown promising success in drug discovery against NDDs, still their use is associated with several ethical issues which need to be solved in the upcoming time.
神经退行性疾病（NDDs）是一种多方面的复杂疾病，目前在全球范围内给健康和经济带来了巨大的负担。NDDs 的多因素性质给药物发现带来了巨大的挑战，目前正在不断努力寻找合适的治疗候选物。大自然拥有丰富的活性物质，自古以来就治愈了人类。天然产物在许多方面都优于传统的合成药物，过去几年，科学家们已经将目光转向探索天然产物的治疗潜力。天然化合物对内源性配体的结构模拟使它们成为预防 NDDs 发展的潜在治疗候选物。在本次综述中，作者总结了各种 NDD 的人口统计学事实，包括阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿病（HD）和各种类型的脑硬化。还包括了天然来源的新活性物质的重要发现及其对 NDD 的治疗潜力。此外，还列出了天然产物的临床试验和专利的描述。尽管天然产物在对抗 NDD 的药物发现方面取得了有希望的成功，但它们的使用仍然存在一些需要在未来解决的伦理问题。
