Mittal Ravi Kumar, Aggarwal Meenu, Khatana Kavita, Purohit Priyank
Department of Pharmacy, HIMT, Gautam Budha Nagar, Greater Noida, Uttar Pradesh, 201308, India.
Department of Natural Product, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, SAS Nagar, Punjab-160062, India.
Med Chem. 2022;19(1):31-46. doi: 10.2174/1573406418666220303151919.
This review aims to provide a comprehensive report on the quinoline ring with respect to its synthesis, reactivity, and therapeutic values. The reactivity of quinoline for the metal, electrophile, and other reactive counterparts defines the shape of the quinoline pharmacophore, which is an important part of this report; moreover, its spectroscopic characteristics have been included herein with suitable illustration. The quinoline and its derivatives have been presented as well as the general synthetic approaches along with the new developments in the catalytic system; the relevant information is also summarized under the various separate activity classes. The synthesis of heterocyclic scaffolds has been a concern for scientists, so herein we have tried to include the synthetic parameters of quinoline with regard to the important pharmacological aspects.
本综述旨在提供一份关于喹啉环的全面报告，内容涉及其合成、反应性和治疗价值。喹啉与金属、亲电试剂及其他反应性物质的反应性决定了喹啉药效团的形态，这是本报告的重要组成部分；此外，本文还通过适当的图示介绍了其光谱特征。文中展示了喹啉及其衍生物、一般合成方法以及催化体系的新进展；相关信息也在各个单独的活性类别下进行了总结。杂环骨架的合成一直是科学家们关注的问题，因此在本文中，我们试图纳入与重要药理学方面相关的喹啉合成参数。
