Department of Chemistry, University of Lucknow, Lucknow-226007, UP, India.
Curr Top Med Chem. 2024;24(27):2377-2419. doi: 10.2174/0115680266314303240830074056.
Among heterocyclic compounds, quinoline is one of the best ubiquitous heterocyclic rings for medicinal chemistry purposes. Quinoline appears to be a powerful chemical structure to develop new drug entities. The quinoline derivatives own a wide array of biological activities such as anticancer, antimalarial, antimicrobial, anti-inflammatory, anti-leishmanial, etc. Because of the wide spectrum of bioactivities, the scientific communities are still looking for more efficient synthetic routes to form quinoline derivatives. Therefore, the primary focus of this review is to provide a thorough and inclusive, updated report on quinoline analogs that may pave the way for more efficient drug development.
在杂环化合物中，喹啉是医药化学中用途最广泛的杂环之一。喹啉似乎是开发新药物实体的强大化学结构。喹啉衍生物具有广泛的生物活性，如抗癌、抗疟、抗菌、抗炎、抗利什曼原虫等。由于其广泛的生物活性，科学界仍在寻找更有效的合成途径来合成喹啉衍生物。因此，本综述的主要重点是提供关于喹啉类似物的全面、综合和最新报告，为更有效的药物开发铺平道路。
