Division of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan.
Division of Oral Rehabilitation, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan.
In Vivo. 2022 Mar-Apr;36(2):643-648. doi: 10.21873/invivo.12748.
BACKGROUND/AIM: The aim of this study was to evaluate the effect of low-intensity pulsed ultrasound (LIPUS) on bone metabolism during the healing period in rat tibiae bone defects using micro-computed tomography (micro CT) imaging for three-dimensional morphological evaluation.
The right tibia received ultrasound exposure (US group) every day, whereas the opposite side served as a control (Control group). At 1, 2, and 3 weeks after the operation, micro CT was performed, and the volume and surface area of new bone formation in the bone defects was evaluated three-dimensionally.
Bone volume (BV) and bone surface (BS) in the tibiae of both the US and Control groups demonstrated the highest values 1 week after the operation, with no significant differences between the groups. At 2 weeks after the operation, the BV and BS values in both groups had decreased, but the decrease was smaller in the US group than the Control group. At 3 weeks after the operation, the BV and BS values in the Control group were significantly lower than those in the US group.
LIPUS stimulation can prevent bone loss during the healing of bone defects.
背景/目的：本研究旨在通过微计算机断层扫描（micro CT）成像进行三维形态评估，评估低强度脉冲超声（LIPUS）对大鼠胫骨骨缺损愈合期骨代谢的影响。
右侧胫骨每天接受超声照射（US 组），而对侧作为对照（对照组）。术后 1、2 和 3 周，进行 micro CT 检查，三维评估骨缺损中新骨形成的体积和表面积。
术后 1 周，两组胫骨的骨体积（BV）和骨表面（BS）均达到最高值，两组间无显著差异。术后 2 周，两组 BV 和 BS 值均下降，但 US 组下降幅度小于对照组。术后 3 周，对照组的 BV 和 BS 值明显低于 US 组。
LIPUS 刺激可防止骨缺损愈合过程中的骨质流失。
