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超声的非热细胞效应

Non-thermal cellular effects of ultrasound.

作者信息

Dyson M

出版信息

Br J Cancer Suppl. 1982 Mar;5:165-71.

PMID:6950755
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149297/
Abstract

The cellular effects of ultrasound can be grouped into those which are predominantly thermal in origin and those which are, at least in part, non-thermal. Cellular effects of ultrasound generally acknowledged to be essentially non-thermal include changes associated with standing waves, acoustic streaming, microstreaming and cavitation; they have been demonstrated in vitro and may, in many instances, also occur in vivo. While some stimulate cell activity and can be exploited in ultrasonic therapy, others are potentially hazardous and must be avoided. Examples of experimentally-demonstrated cellular effects in which non-thermal, ultrasonically-induced events are involved are described, together with the mechanisms considered to be involved in producing them. The relevance of such effects to the safe and beneficial use of ultrasound in diagnosis and therapy is considered.

摘要

超声的细胞效应可分为主要源于热效应的和至少部分是非热效应的。一般认为本质上是非热效应的超声细胞效应包括与驻波、声流、微流和空化相关的变化;这些效应已在体外得到证实,并且在许多情况下也可能在体内发生。虽然有些效应能刺激细胞活性并可用于超声治疗,但其他一些效应可能具有潜在危害,必须避免。文中描述了涉及非热超声诱导事件的实验证明的细胞效应实例,以及被认为与这些效应产生有关的机制。还考虑了这些效应与超声在诊断和治疗中的安全和有益应用的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/2149297/6408934623af/brjcancersuppl00063-0179-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/2149297/f7256bfa4360/brjcancersuppl00063-0175-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/2149297/063179e6abb5/brjcancersuppl00063-0176-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/2149297/729cf21e4222/brjcancersuppl00063-0178-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/2149297/6408934623af/brjcancersuppl00063-0179-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/2149297/f7256bfa4360/brjcancersuppl00063-0175-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/2149297/063179e6abb5/brjcancersuppl00063-0176-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/2149297/729cf21e4222/brjcancersuppl00063-0178-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1133/2149297/6408934623af/brjcancersuppl00063-0179-a.jpg

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本文引用的文献

1
The role of ultrasound-induced cavitation in the 'in vitro' stimulation of collagen synthesis in human fibroblasts.超声诱导空化在体外刺激人成纤维细胞胶原蛋白合成中的作用。
Ultrasonics. 1980 Jan;18(1):33-7. doi: 10.1016/0041-624x(80)90050-5.
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Ultrasonically induced cavitation in vivo.体内超声诱导空化
Br J Cancer Suppl. 1982 Mar;5:151-5.
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The stimulation of tissue regeneration by means of ultrasound.
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超声在骨折治疗中的作用是什么?:骨折、骨延迟愈合及骨折相关感染的诊断与治疗潜力
Bone Joint Res. 2019 Aug 2;8(7):304-312. doi: 10.1302/2046-3758.87.BJR-2018-0215.R2. eCollection 2019 Jul.
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Lipid Coated Microbubbles and Low Intensity Pulsed Ultrasound Enhance Chondrogenesis of Human Mesenchymal Stem Cells in 3D Printed Scaffolds.脂质包覆微泡和低强度脉冲超声增强三维打印支架中人骨髓间充质干细胞的软骨分化。
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Effects of ultrasound on estradiol level, bone mineral density, bone biomechanics and matrix metalloproteinase-13 expression in ovariectomized rabbits.超声对去卵巢兔雌二醇水平、骨密度、骨生物力学及基质金属蛋白酶-13表达的影响
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Ultrasound stimulation increases proliferation of MC3T3-E1 preosteoblast-like cells.超声刺激可增加MC3T3-E1前成骨样细胞的增殖。
J Ther Ultrasound. 2014 Jan 2;2:1. doi: 10.1186/2050-5736-2-1. eCollection 2014.
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In vitro effects of low-intensity pulsed ultrasound stimulation on the osteogenic differentiation of human alveolar bone-derived mesenchymal stem cells for tooth tissue engineering.体外低强度脉冲超声刺激对人牙槽骨间充质干细胞成骨分化在牙组织工程中的作用。
Biomed Res Int. 2013;2013:269724. doi: 10.1155/2013/269724. Epub 2013 Sep 30.
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The production of blood cell stasis and endothelial damage in the blood vessels of chick embryos treated with ultrasound in a stationary wave field.在驻波场中用超声处理的鸡胚血管内血细胞淤滞和内皮损伤的产生。
Ultrasound Med Biol. 1974 Mar;1(2):133-48. doi: 10.1016/0301-5629(74)90003-9.
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Stimulation of healing of varicose ulcers by ultrasound.
Ultrasonics. 1976 Sep;14(5):232-6. doi: 10.1016/0041-624x(76)90024-x.
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The role of cavitation in the in vitro stimulation of protein synthesis in human fibroblasts by ultrasound.空化在超声对人成纤维细胞蛋白质合成的体外刺激中的作用。
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