Hegsted D M
Am J Clin Nutr. 1986 Aug;44(2):299-305. doi: 10.1093/ajcn/44.2.299.
The data from the literature in which the serum-cholesterol response has been measured following a change in cholesterol intake have been re-evaluated. The overall data appear to be best explained by exponential equations. However, very large differences in response have been reported for similar changes in cholesterol intake and no predictive equation can explain such values. It is concluded that over the range of cholesterol intakes of practical interest--0 to 400 mg/1000 kcal--the usual response is approximately linear, each 1 mg/1000 kcal resulting in an expected increase of serum cholesterol of approximately 0.1 mg/dl. With a 2500 kcal diet, an increase in intake of 100 mg/day would be expected to increase serum cholesterol by approximately 4 mg/dl.
对那些在胆固醇摄入量改变后测量血清胆固醇反应的文献数据进行了重新评估。总体数据似乎用指数方程解释最为合适。然而，对于胆固醇摄入量的相似变化，已报道的反应存在非常大的差异，没有预测方程能够解释这些数值。得出的结论是，在实际关注的胆固醇摄入量范围（0至400毫克/1000千卡）内，通常的反应近似呈线性，每1毫克/1000千卡会导致血清胆固醇预期增加约0.1毫克/分升。对于一份2500千卡的饮食，每日摄入量增加100毫克预计会使血清胆固醇升高约4毫克/分升。
