Department of Psychiatry, Hanyang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430051, China.
Comput Math Methods Med. 2022 Feb 22;2022:6580030. doi: 10.1155/2022/6580030. eCollection 2022.
To investigate the changes in mental state and serum prolactin levels in patients with schizophrenia and depression after receiving the combination therapy of amisulpride and chloroprothixol tablets.
A total of 148 schizophrenic patients with depression were randomly divided into control group ( = 73) and study group ( = 75). The control group was treated with clopidothiol, and the study group was treated with amisulpride. Symptom scores, sleep quality, adverse reactions, therapeutic effects, prolactin, and progesterone levels, HAMD, PANSS, and PSP scores were compared between the two groups.
The symptom scores of both groups were significantly reduced, but when compared to the control group, the symptom scores of the research group were significantly reduced more significantly ( < 0.05); serum GDNF levels of both groups were significantly increased, while serum NSE, IL-1, and MBP levels were significantly reduced ( < 0.05). However, the research group altered more substantially ( < 0.05) than the control group; the overall PSQI score of the research group was lower ( < 0.05) than the control group; and the incidence of adverse responses in the control and study groups was 12.3 percent and 4.0 percent. The research group had a lower rate of adverse responses ( < 0.05) than the control group, and the effective treatment of the control and research groups was 82.2 percent and 98.7%, respectively. The research group had a lower rate of adverse reactions ( < 0.05) than the control group, while the control and research groups' successful treatment rates were 82.2 percent and 98.7%, respectively. When compared to the control group, the research group had a greater treatment efficiency ( < 0.05); blood prolactin and progesterone levels were considerably lowered in both groups, but the reductions in the research group were more evident ( < 0.05). Both groups had considerably lower HAMD and PANSS scores, and both had significantly higher PSP scores, although the difference in the research group was more evident ( < 0.05).
For people with schizophrenia and depression, a combination of amisulpride and chloroprothixol pills has a considerable effect. It can help patients with their clinical symptoms and sleep quality while also lowering their serum prolactin levels, which is favorable to their illness recovery. As a result, the combined treatment of amisulpride and chloroprothixol pills deserves to be promoted and used.
研究氨磺必利与氯普噻吨联合治疗对精神分裂症合并抑郁患者精神状态和血清催乳素水平的影响。
选取我院收治的 148 例精神分裂症合并抑郁患者，随机分为对照组（n=73）和观察组（n=75）。对照组采用氯普噻吨治疗，观察组采用氨磺必利治疗。比较两组患者的症状评分、睡眠质量、不良反应、治疗效果、催乳素和孕酮水平、汉密尔顿抑郁量表（HAMD）评分、阳性和阴性症状量表（PANSS）评分、个人和社会表现量表（PSP）评分。
两组患者的症状评分均显著降低，但观察组的症状评分显著低于对照组（P<0.05）；两组患者的血清 GDNF 水平均显著升高，血清 NSE、IL-1 和 MBP 水平均显著降低（P<0.05），但观察组的改变更显著（P<0.05）；观察组的总体 PSQI 评分低于对照组（P<0.05）；对照组和观察组的不良反应发生率分别为 12.3%和 4.0%，观察组的不良反应发生率显著低于对照组（P<0.05），对照组和观察组的有效治疗率分别为 82.2%和 98.7%，观察组的不良反应发生率显著低于对照组（P<0.05），观察组的治疗有效率显著高于对照组（P<0.05）；与对照组相比，观察组的治疗效率更高（P<0.05）；两组患者的血清催乳素和孕酮水平均显著降低，但观察组的降低更显著（P<0.05）；两组患者的 HAMD 和 PANSS 评分均显著降低，PSP 评分均显著升高，但观察组的差异更显著（P<0.05）。
氨磺必利与氯普噻吨联合治疗精神分裂症合并抑郁患者具有显著疗效，能够改善患者的临床症状和睡眠质量，降低患者的血清催乳素水平，有利于患者的病情康复，值得临床推广应用。
